English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration.

Reiner, O., Albrecht, U., Gordon, M., Chianese, K. A., Wong, C., Gal-Gerber, O., et al. (1995). Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration. The Journal of Neuroscience, 15(5), 3730-3738.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-512F-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C4A1-9
Genre: Journal Article

Files

show Files
hide Files
:
1578127.pdf (Publisher version), 7MB
 
File Permalink:
-
Name:
1578127.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute), MBPC; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Reiner, O., Author
Albrecht, U., Author
Gordon, M., Author
Chianese, K. A., Author
Wong, C., Author
Gal-Gerber, O., Author
Sapir, T., Author
Siracusa, L. D., Author
Buchberg, A. M., Author
Caskey, C. T., Author
Eichele, G.1, Author              
Affiliations:
1Department of Molecular Embryology, Max Planck Institute for Experimental Endocrinology, Max Planck Society, ou_1565140              

Content

show
hide
Free keywords: -
 Abstract: Miller-Dieker lissencephaly syndrome (MDS) is a human developmental brain malformation caused by neuronal migration defects resulting in abnormal layering of the cerebral cortex. LIS1, the gene defective in MDS, encodes a subunit of brain platelet-activating factor (PAF) acetylhydrolase which inactivates PAF, a neuroregulatory molecule. We have isolated murine cDNAs homologous to human LIS1 and mapped these to three different chromosomal loci (Lis1, Lis3, Lis4). The predicted sequences of murine Lis1 protein and its human homolog LIS1 are virtually identical. In the developing mouse and human, Lis1 and LIS1 genes were strongly expressed in the cortical plate. In the adult mouse Lis1 transcripts were abundant in cortex and hippocampus. The direct correlation between cortical defects in MDS patients and Lis1 expression in the murine cortex suggest that the mouse is a model system suitable to study the mechanistic basis of this intriguing genetic disease.

Details

show
hide
Language(s): eng - English
 Dates: 1995-05-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: The Journal of Neuroscience
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 15 (5) Sequence Number: - Start / End Page: 3730 - 3738 Identifier: -