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  Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum

Mund, T., Gewies, A., Schoenfeld, N., Bauer, M. K. A., & Grimm, S. (2003). Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum. The FASEB Journal, 17(2), U307-U329.

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Genre: Journal Article
Alternative Title : FASEB J.

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 Creators:
Mund, T.1, Author              
Gewies, A.1, Author              
Schoenfeld, N.1, Author              
Bauer, M. K. A.1, Author              
Grimm, S.1, Author              
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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Free keywords: cell death; caspase-8; BH3 domain; tumors; Bap31
 Abstract: We have isolated Spike, a novel and evolutionary conserved BH3- only protein. BH3-only proteins constitute a family of apoptosis inducers that mediate proapoptotic signals. In contrast to most proteins of this family, Spike was not found to be associated with mitochondria. Furthermore, unlike the known BH3-only proteins, Spike could not interact with all tested Bcl-2 family members, despite its BH3 domain being necessary for cell killing. Our findings indicate that Spike is localized to the endoplasmic reticulum. The endoplasmic reticulum is an organelle that has only recently been implicated in regulation of apoptosis. At this locale, Spike interacts with Bap31, an adaptor protein for pro-caspase-8 and Bcl-XL. In doing so, Spike is able to inhibit the formation of a complex between Bap31 and the antiapoptotic Bcl-XL protein. Furthermore, Spike transmits the signal of specific death receptors. Its down-regulation in certain tumors suggests that Spike may also play a role in tumorigenesis. Our findings add new insight for how BH3-only and antiapoptotic Bcl-2 proteins regulate cell death.

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Language(s): eng - English
 Dates: 2003-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 41772
ISI: 000181456900016
 Degree: -

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Title: The FASEB Journal
  Alternative Title : FASEB J.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 17 (2) Sequence Number: - Start / End Page: U307 - U329 Identifier: ISSN: 0892-6638