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  Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70

Young, J. C., Hoogenraad, N. J., & Hartl, F. U. (2003). Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell, 112(1), 41-50.

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Genre: Journal Article
Alternative Title : Cell

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 Creators:
Young, J. C.1, Author              
Hoogenraad, N. J., Author
Hartl, F. U.1, Author              
Affiliations:
1Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565152              

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 Abstract: The role of cytosolic factors in protein targeting to mitochondria is poorly understood. Here, we show that in mammals, the cytosolic chaperones Hsp90 and Hsp70 dock onto a specialized TPR domain in the import receptor Tom70 at the outer mitochondrial membrane. This interaction serves to deliver a set of preproteins to the receptor for subsequent membrane translocation dependent on the Hsp90 ATPase. Disruption of the chaperone/Tom70 recognition inhibits the import of these preproteins into mitochondria. In yeast, Hsp70 rather than Hsp90 is used in import, and Hsp70 docking is required for the formation of a productive preprotein/Tom70 complex. We outline a novel mechanism in which chaperones are recruited for a specific targeting event by a membrane-bound receptor.

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Language(s): eng - English
 Dates: 2003-01-10
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 41764
ISI: 000181191500005
 Degree: -

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Title: Cell
  Alternative Title : Cell
Source Genre: Journal
 Creator(s):
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Publ. Info: -
Pages: - Volume / Issue: 112 (1) Sequence Number: - Start / End Page: 41 - 50 Identifier: ISSN: 0092-8674