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  Application of NMR in structural proteomics: Screening for proteins amenable to structural analysis

Rehm, T., Huber, R., & Holak, T. A. (2002). Application of NMR in structural proteomics: Screening for proteins amenable to structural analysis. Structure, 10(12), 1613-1618.

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Genre: Journal Article
Alternative Title : Structure

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 Creators:
Rehm, T.1, Author           
Huber, R.1, Author           
Holak, T. A.2, Author           
Affiliations:
1Huber, Robert / Structure Research, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565155              
2Holak, Tad / NMR Spectroscopy, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565154              

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Free keywords: NMR; X-ray crystallography; screening; protein characterization; proteomics; structural analysis
 Abstract: In the time of structural proteomics when protein structures are targeted on a genome-wide scale, the detection of "well- behaved" proteins that would yield good quality NMR spectra or X-ray images is the key to high-throughput structure determination. Already, simple one-dimensional proton NMR spectra provide enough information for assessing the folding properties of proteins. Heteronuclear two-dimensional spectra are routinely used for screenings that reveal structural, as well as binding, properties of proteins. NMR can thus provide important information for optimizing conditions for protein constructs that are amenable to structural studies.

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Language(s): eng - English
 Dates: 2002-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 41405
ISI: 000182039500004
 Degree: -

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Title: Structure
  Alternative Title : Structure
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 10 (12) Sequence Number: - Start / End Page: 1613 - 1618 Identifier: ISSN: 0969-2126