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  Brevican-deficient mice display impaired hippocampal CA1 long- term potentiation but show no obvious deficits in learning and memory

Brakebusch, C., Seidenbecher, C. I., Asztely, F., Rauch, U., Matthies, H., Meyer, H., et al. (2002). Brevican-deficient mice display impaired hippocampal CA1 long- term potentiation but show no obvious deficits in learning and memory. Molecular and Cellular Biology, 22(21), 7417-7427.

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Genre: Journal Article
Alternative Title : Mol. Cell. Biol.

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 Creators:
Brakebusch, C.1, Author              
Seidenbecher, C. I., Author
Asztely, F., Author
Rauch, U., Author
Matthies, H., Author
Meyer, H.2, Author              
Krug, M., Author
Bockers, T. M., Author
Zhou, X. H., Author
Kreutz, M. R., Author
Montag, D., Author
Gundelfinger, E. D., Author
Fässler, R.2, Author              
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              
2Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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 Abstract: Brevican is a brain-specific proteoglycan which is found in specialized extracellular matrix structures called perineuronal nets. Brevican increases the invasiveness of glioma cells in vivo and has been suggested to play a role in central nervous system fiber tract development. To study the role of brevican in the development and function of the brain, we generated mice lacking a functional brevican gene. These mice are viable and fertile and have a normal life span. Brain anatomy was normal, although alterations in the expression of neurocan were detected. Perineuronal nets formed but appeared to be less prominent in mutant than in wild-type mice. Brevican-deficient mice showed significant deficits in the maintenance of hippocampal long-term potentiation (LTP). However, no obvious impairment of excitatory and inhibitory synaptic transmission was found, suggesting a complex cause for the LTP defect. Detailed behavioral analysis revealed no statistically significant deficits in learning and memory. These data indicate that brevican is not crucial for brain development but has restricted structural and functional roles.

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Language(s): eng - English
 Dates: 2002-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 41546
ISI: 000178586900006
 Degree: -

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Title: Molecular and Cellular Biology
  Alternative Title : Mol. Cell. Biol.
Source Genre: Journal
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Pages: - Volume / Issue: 22 (21) Sequence Number: - Start / End Page: 7417 - 7427 Identifier: ISSN: 0270-7306