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  Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alpha v integrins

McCarty, J. H., Monahan-Earley, R. A., Brown, L. F., Keller, M., Gerhardt, H., Rubin, K., et al. (2002). Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alpha v integrins. Molecular and Cellular Biology, 22(21), 7667-7677.

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Genre: Journal Article
Alternative Title : Mol. Cell. Biol.

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 Creators:
McCarty, J. H., Author
Monahan-Earley, R. A., Author
Brown, L. F., Author
Keller, M.1, Author              
Gerhardt, H., Author
Rubin, K., Author
Shani, M., Author
Dvorak, H. F., Author
Wolburg, H., Author
Bader, B. L.1, Author              
Dvorak, A. M., Author
Hynes, R. O., Author
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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 Abstract: Mouse embryos genetically null for the alphav integrin subunit develop intracerebral hemorrhages at midgestation and die shortly after birth. A key question is whether the hemorrhage arises from primary defects in vascular endothelial cells or pericytes or from other causes. We have previously reported normal initiation of cerebral vessels comprising branched tubes of endothelial cells. Here we show that the onset of hemorrhage is not due to defects in pericyte recruitment. Additionally, most alphav-null vessels display ultrastructurally normal endothelium-pericyte associations and normal interendothelial cell junctions. Thus, endothelial cells and pericytes appear to establish their normal relationships in cerebral microvessels. However, by both light and electron microscopy, we detected defective associations between cerebral microvessels and the surrounding brain parenchyma, composed of neuroepithelial cells, glia, and neuronal precursors. These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells.

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Language(s): eng - English
 Dates: 2002-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 41779
ISI: 000178586900030
 Degree: -

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Title: Molecular and Cellular Biology
  Alternative Title : Mol. Cell. Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 22 (21) Sequence Number: - Start / End Page: 7667 - 7677 Identifier: ISSN: 0270-7306