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  Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model

Arlt, M., Kopitz, C., Pennington, C., Watson, K. L. M., Krell, H. W., Bode, W., et al. (2002). Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model. Cancer Research, 62(19), 5543-5550.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-6E2A-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-6E2B-1
Genre: Journal Article
Alternative Title : Cancer Res.

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 Creators:
Arlt, M., Author
Kopitz, C., Author
Pennington, C., Author
Watson, K. L. M., Author
Krell, H. W., Author
Bode, W.1, 2, 3, Author              
Gansbacher, B., Author
Khokha, R., Author
Edwards, D. R., Author
Krüger, A., Author
Affiliations:
1Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              
2Huber, Robert / Structure Research, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565155              
3Conti, Elena / Structural Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565144              

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 Abstract: The recognition that matrix metalloproteinases (MMPs) facilitate tumor cell invasion and metastasis has led to the development of synthetic MMP inhibitors (MMPIs) as cancer therapeutic agents. Because several Phase III trials failed recently to show efficacy of broad-spectrum MMPIs in advanced cancer, the feasibility of MMPs as therapeutic targets has been challenged. However, it has not yet been determined whether MMPIs that have increased specificity may have greater benefit. We show that MMP-9 expression closely correlates with the progression of liver metastasis in a T-cell lymphoma model. MMPIs with greater selectivity/specificity for MMP-9 in vitro showed greater efficacy against liver metastasis in vivo. These data demonstrate a link between increased specificity of MMPIs and enhanced anticancer activity.

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Language(s): eng - English
 Dates: 2002-10-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 41544
ISI: 000178378200026
 Degree: -

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Title: Cancer Research
  Alternative Title : Cancer Res.
Source Genre: Journal
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Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 62 (19) Sequence Number: - Start / End Page: 5543 - 5550 Identifier: ISSN: 0008-5472