English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  SMN-mediated assembly of RNPs: a complex story

Meister, G., Eggert, C., & Fischer, U. (2002). SMN-mediated assembly of RNPs: a complex story. Trends in Cell Biology, 12(10), 472-478.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Trends Cell Biol.

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Meister, G.1, Author              
Eggert, C.1, Author              
Fischer, U.1, Author              
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

Content

show
hide
Free keywords: -
 Abstract: Although many RNA-protein complexes or ribonucleoproteins (RNPs) assemble spontaneously in vitro, little is known about how they form in the environment of a living cell. Insight into RNP assembly has come unexpectedly from functional analyses of the survival motor neuron (SMN) protein, a gene product that is affected in the neuromuscular disease spinal muscular atrophy. These studies show that the assembly of spliceosomal U-rich small nuclear RNPs in vivo depends on the activity of two large protein complexes, one of which contains the SMN protein. These complexes might also facilitate the assembly of other cellular RNPs.

Details

show
hide
Language(s): eng - English
 Dates: 2002-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 41693
ISI: 000178297400011
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Trends in Cell Biology
  Alternative Title : Trends Cell Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 12 (10) Sequence Number: - Start / End Page: 472 - 478 Identifier: ISSN: 0962-8924