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  Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2

Martin-Lluesma, S., Stucke, V. M., & Nigg, E. A. (2002). Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science, 297(5590), 2267-2270.

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Genre: Journal Article
Alternative Title : Science

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 Creators:
Martin-Lluesma, S.1, Author
Stucke, V. M.2, Author              
Nigg, E. A.2, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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 Abstract: The spindle checkpoint delays sister chromatid separation until all chromosomes have undergone bipolar spindle attachment. Checkpoint failure may result in chromosome mis-segregation and may contribute to tumorigenesis. We showed that the human protein Hec1 was required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores. Depletion of Hec1 impaired chromosome congression and caused persistent activation of the spindle checkpoint, indicating that high steady-state levels of Mad1/Mad2 complexes at kinetochores were not essential for checkpoint signaling. Simultaneous depletion of Hec1 and Mad2 caused catastrophic mitotic exit, making Hec1 an attractive target for the selective elimination of spindle checkpoint deficient cells.

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Language(s): eng - English
 Dates: 2002-09-27
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 41545
ISI: 000178222000049
 Degree: -

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Title: Science
  Alternative Title : Science
Source Genre: Journal
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Pages: - Volume / Issue: 297 (5590) Sequence Number: - Start / End Page: 2267 - 2270 Identifier: ISSN: 0036-8075