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  Binding and docking of synthetic heterotrimeric collagen type IV peptides with alpha1 beta1 integrin

Saccà, B., Sinner, E.-K., Kaiser, J., Lübken, C., Eble, J. A., & Moroder, L. (2002). Binding and docking of synthetic heterotrimeric collagen type IV peptides with alpha1 beta1 integrin. ChemBioChem, 3(9), 904-907.

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Genre: Journal Article
Alternative Title : Chembiochem

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 Creators:
Saccà, B.1, Author              
Sinner, E.-K.2, Author              
Kaiser, J., Author
Lübken, C., Author
Eble, J. A., Author
Moroder, L.1, Author              
Affiliations:
1Moroder, Luis / Bioorganic Chemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565160              
2Oesterhelt, Dieter / Membrane Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565164              

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Free keywords: binding affinity; cell adhesion; collagen; integrins; structure elucidation
 Abstract: Checking the register: Cell-adhesion processes are mediated by conformation-dependent binding of collagen type IV to integrins, Two heterotrimeric collagen peptides that contain the residue-457-468 sequence of the cell-adhesion epitope of the alpha1 and alpha2 chains in collagen type IV were synthesized and the three chains were assembled into the alpha1alpha2alpha1' and alpha2alpha1alpha1' registers (see figure). Binding and modeling experiments allowed identification of the latter register as the most plausible alignment of the chains in natural collagen type IV.

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Language(s): eng - English
 Dates: 2002-09-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 41664
ISI: 000177847600015
 Degree: -

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Title: ChemBioChem
  Alternative Title : Chembiochem
Source Genre: Journal
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Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 3 (9) Sequence Number: - Start / End Page: 904 - 907 Identifier: ISSN: 1439-4227