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  Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy

Enge, M., Bjarnegard, M., Gerhardt, H., Gustafsson, E., Kalen, M., Asker, N., et al. (2002). Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO Journal, 21(16), 4307-4316.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-6E82-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-6E83-8
Genre: Journal Article
Alternative Title : Embo J.

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 Creators:
Enge, M., Author
Bjarnegard, M., Author
Gerhardt, H., Author
Gustafsson, E., Author
Kalen, M., Author
Asker, N., Author
Hammes, H. P., Author
Shani, M., Author
Fässler, R.1, Author              
Betsholtz, C., Author
Affiliations:
1Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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Free keywords: Cre-loxP system; diabetes; pericytes; platelet-derived growth factor; retinopathy
 Abstract: Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to pericyte deficiency, prenatal lethality has so far precluded analysis of postnatal consequences in the retina. We now report that endothelium-restricted ablation of platelet-derived growth factor-B generates viable mice with extensive inter- and intra-individual variation in the density of pericytes throughout the CNS. We found a strong inverse correlation between pericyte density and the formation of a range of retinal microvascular abnormalities strongly reminiscent of those seen in diabetic humans. Proliferative retinopathy invariably developed when pericyte density was <50% of normal. Our data suggest that a reduction of the pericyte density is sufficient to cause retinopathy in mice, implying that pericyte loss may also be a causal pathogenic event in human diabetic retinopathy.

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Language(s): eng - English
 Dates: 2002-08-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 41642
ISI: 000177355300011
 Degree: -

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Title: EMBO Journal
  Alternative Title : Embo J.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 21 (16) Sequence Number: - Start / End Page: 4307 - 4316 Identifier: ISSN: 0261-4189