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  A critical function of the pial basement membrane in cortical histogenesis

Halfter, W., Dong, S. C., Yip, Y. P., Willem, M., & Mayer, U. (2002). A critical function of the pial basement membrane in cortical histogenesis. Journal of Neuroscience, 22(14), 6029-6040.

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Genre: Journal Article
Alternative Title : J. Neurosci.

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 Creators:
Halfter, W., Author
Dong, S. C., Author
Yip, Y. P., Author
Willem, M.1, Author              
Mayer, U.1, Author              
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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Free keywords: basement membrane; laminin; cortical dysplasia; Cajal-Retzius cells; nidogen; radial glia cells
 Abstract: Mice with a targeted deletion of the nidogen-binding site of laminin gamma1 were used to study the function of the pial basement membrane in cortical histogenesis. The pial basement membrane in the mutant embryos assembled but was unstable and disintegrated at random segments. In segments with a disrupted basement membrane, radial glia cells were retracted from the pial surface, and radially migrating neurons, including Cajal- Retzius cells and cortical plate neurons, passed the meninges or terminated their migration prematurely. By correlating the disruptions in the pial basal lamina with changes in the morphology of radial glia cells, the aberrant migration of Cajal-Retzius cells, and subsequent dysplasia of cortical plate neurons, the present data establish a causal relationship of proper cortical histogenesis with the presence of an intact pial basement membrane.

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Language(s): eng - English
 Dates: 2002-07-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 41649
ISI: 000176840500027
 Degree: -

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Title: Journal of Neuroscience
  Alternative Title : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 22 (14) Sequence Number: - Start / End Page: 6029 - 6040 Identifier: ISSN: 0270-6474