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  Molecular portrait of human kidney carcinomas: The cDNA microarray profiling of kinases and phosphatases involved in the cell signaling control

Cheburkin, Y. V., Knyazeva, T. G., Peter, S., Knyazev, Y. P., Karelin, M. I., Shkolnik, M. I., et al. (2002). Molecular portrait of human kidney carcinomas: The cDNA microarray profiling of kinases and phosphatases involved in the cell signaling control. Molecular Biology, 36(3), 376-384.

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Genre: Journal Article
Alternative Title : Mol. Biol.

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 Creators:
Cheburkin, Y. V.1, 2, Author              
Knyazeva, T. G.1, Author              
Peter, S., Author
Knyazev, Y. P.3, Author              
Karelin, M. I., Author
Shkolnik, M. I., Author
Evtushenko, V. I., Author
Hanson, K., Author
Ullrich, A.1, Author              
Knyazev, P. G.1, Author              
Affiliations:
1Ullrich, Axel / Molecular Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565172              
2Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              
3External Organizations, ou_persistent22              

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Free keywords: molecular oncology; kidney carcinoma; cDNA arrays; expression; clusters; oncogencs; tyrosine kinases; tyrosine phosphatases; dual specificity phosphatases
 Abstract: Hybridization with cDNA arrays was used to obtain expression profiles of 214 protein-tyrosine kinase, protein-tyrosine phosphatase, dual specificity phosphatase, and other genes for kidney carcinomas (KC) and normal kidney tissues of 34 patients and for seven carcinoma cell lines. Computer analysis revealed three clusters of genes coexpressed in KC. The proliferating- cell gene cluster included MET, VIM, MYC, TOM, PCNA. The neoangiogenesis and blood-cell gene cluster included LCK, HCK, FGR, MAIM, CSFR1, VEGF, FLT1, and KDR. The cluster corresponding to normal, differentiated kidney cells included ERBB2 (HER2) for receptor protein-tyrosine kinase, several phosphatase genes (PTPRE, PTPRB, DUSP9), and EGF. The results suggested that MET, DUSP9, PCNA, TOM, and VIM may serve as diagnostic and prognostic markers in KC. Tubulin and topoisomerase II were assumed to be promising targets for cell proliferation inhibitors in KC.

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Language(s): eng - English
 Dates: 2002-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 31383
ISI: 000176468800015
 Degree: -

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Title: Molecular Biology
  Alternative Title : Mol. Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 36 (3) Sequence Number: - Start / End Page: 376 - 384 Identifier: ISSN: 0026-8933