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  The dissociation of cohesin from chromosomes in prophase is regulated by polo-like kinase

Sumara, I., Vorlaufer, E., Stukenberg, P. T., Kelm, O., Redemann, N., Nigg, E. A., et al. (2002). The dissociation of cohesin from chromosomes in prophase is regulated by polo-like kinase. Molecular Cell, 9(3), 515-525.

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Genre: Journal Article
Alternative Title : Mol. Cell

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 Creators:
Sumara, I., Author
Vorlaufer, E., Author
Stukenberg, P. T., Author
Kelm, O.1, Author              
Redemann, N., Author
Nigg, E. A.1, Author              
Peters, J. M., Author
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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 Abstract: The separation of sister chromatids in anaphase depends on the dissociation of cohesin from chromosomes. In vertebrates, some cohesin is removed from chromosomes at the onset of anaphase by proteolytic cleavage. In contrast, the bulk of cohesin is removed from chromosomes already in prophase and prometaphase by an unknown mechanism that does not involve cohesin cleavage. We show that Polo-like kinase is required for the cleavage- independent dissociation of cohesin from chromosomes in Xenopus. Cohesin phosphorylation depends on Polo-like kinase and reduces the ability of cohesin to bind to chromatin. These results suggest that Polo-like kinase regulates the dissociation of cohesin from chromosomes early in mitosis.

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Language(s): eng - English
 Dates: 2002-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 39204
ISI: 000174769300010
 Degree: -

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Title: Molecular Cell
  Alternative Title : Mol. Cell
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 9 (3) Sequence Number: - Start / End Page: 515 - 525 Identifier: ISSN: 1097-2765