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  beta 1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response

Brakebusch, C., Fillatreau, S., Potocnik, A. J., Bungartz, G., Wilhelm, P., Svensson, M., et al. (2002). beta 1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity, 16(3), 465-477.

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Genre: Journal Article
Alternative Title : Immunity

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 Creators:
Brakebusch, C.1, Author              
Fillatreau, S., Author
Potocnik, A. J., Author
Bungartz, G.2, Author              
Wilhelm, P., Author
Svensson, M., Author
Kearney, P., Author
Korner, H., Author
Gray, D., Author
Fässler, R.3, Author              
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              
2External Organizations, ou_persistent22              
3Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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 Abstract: Several experimental evidences suggested that beta1 integrin- mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.

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Language(s): eng - English
 Dates: 2002-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 41843
ISI: 000174572800014
 Degree: -

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Title: Immunity
  Alternative Title : Immunity
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 16 (3) Sequence Number: - Start / End Page: 465 - 477 Identifier: ISSN: 1074-7613