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  beta 1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response

Brakebusch, C., Fillatreau, S., Potocnik, A. J., Bungartz, G., Wilhelm, P., Svensson, M., et al. (2002). beta 1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity, 16(3), 465-477.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-6FA2-B Versions-Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-6FA3-9
Genre: Zeitschriftenartikel
Alternativer Titel : Immunity

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 Urheber:
Brakebusch, C.1, Autor              
Fillatreau, S., Autor
Potocnik, A. J., Autor
Bungartz, G.2, Autor              
Wilhelm, P., Autor
Svensson, M., Autor
Kearney, P., Autor
Korner, H., Autor
Gray, D., Autor
Fässler, R.3, Autor              
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              
2External Organizations, ou_persistent22              
3Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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 Zusammenfassung: Several experimental evidences suggested that beta1 integrin- mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.

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Sprache(n): eng - Englisch
 Datum: 2002-03
 Publikationsstatus: Im Druck publiziert
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 41843
ISI: 000174572800014
 Art des Abschluß: -

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Titel: Immunity
  Alternativer Titel : Immunity
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 16 (3) Artikelnummer: - Start- / Endseite: 465 - 477 Identifikator: ISSN: 1074-7613