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  Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53(-/-) cells

Meraldi, P., Honda, R., & Nigg, E. A. (2002). Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53(-/-) cells. EMBO Journal, 21(4), 483-492.

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Genre: Journal Article
Alternative Title : Embo J.

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 Creators:
Meraldi, P.1, Author              
Honda, R.1, Author              
Nigg, E. A.1, Author              
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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Free keywords: cancer; cell cycle; chromosomal instability; centrosome anomalies
 Abstract: Aberrations in centrosome numbers have long been implicated in aneuploidy and tumorigenesis, but their origins are unknown. Here we have examined how overexpression of Aurora-A kinase causes centrosome amplification in cultured cells. We show that excess Aurora-A does not deregulate centrosome duplication but gives rise to extra centrosomes through defects in cell division and consequent tetraploidization. Overexpression of other mitotic kinases (Polo-like kinase 1 and Aurora-B) also causes multinucleation and concomitant increases in centrosome numbers. Absence of a p53 checkpoint exacerbates this phenotype, providing a plausible explanation for the centrosome amplification typical of p53(-/-) cells. We propose that errors during cell division, combined with the inability to detect the resulting hyperploidy, constitute a major cause for numerical centrosome aberrations in tumors.

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Language(s): eng - English
 Dates: 2002-02-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 39054
ISI: 000174014700001
 Degree: -

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Title: EMBO Journal
  Alternative Title : Embo J.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 21 (4) Sequence Number: - Start / End Page: 483 - 492 Identifier: ISSN: 0261-4189