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  Recombinant Kv1.3 potassium channels stabilize tonic firing of cultured rat hippocampal neurons

Kupper, J., Prinz, A. A., & Fromherz, P. (2002). Recombinant Kv1.3 potassium channels stabilize tonic firing of cultured rat hippocampal neurons. Pflugers Archiv-European Journal of Physiology, 443(4), 541-547.

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Genre: Zeitschriftenartikel
Alternativer Titel : Pflugers Arch.

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 Urheber:
Kupper, J.1, Autor           
Prinz, A. A.1, Autor           
Fromherz, P.1, Autor           
Affiliations:
1Fromherz, Peter / Membrane and Neurophysics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565146              

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Schlagwörter: K+ channel; action potential; hippocampus; margatoxin; green fluorescent protein
 Zusammenfassung: We transfected cultured hippocampal neurons with the cDNA of the voltage-gated K+ channel Kv1.3 to investigate the mechanisms by which a specific ion channel influences excitability. In transfected neurons under voltage clamp we observed an additional outward current that was blocked selectively by margatoxin. Under current-clamp conditions, Kv1.3-expressing neurons fired tonically over a wide range of stimulation intensity. In non-transfected neurons, or in Kv1.3- expressing cells blocked with margatoxin, only a few action potentials were elicited before a stationary depolarized state was reached. We attribute the specific effect of Kv1.3 to its particularly slow deactivation near the resting potential. A computational model showed that a continuous outwards current arises in Kv1.3-expressing neurons during the interspike intervals. It expands the dynamic range so that these neurons still fire tonically at stimulus current intensities at which non-transfected cells have already been driven into a stationary depolarized state.

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Sprache(n): eng - English
 Datum: 2002-02
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 39155
ISI: 000174363000005
 Art des Abschluß: -

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Titel: Pflugers Archiv-European Journal of Physiology
  Alternativer Titel : Pflugers Arch.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 443 (4) Artikelnummer: - Start- / Endseite: 541 - 547 Identifikator: ISSN: 0031-6768