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  Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis

Braun, A., Aszodi, A., Hellebrand, H., Berna, A., Fässler, R., & Brandau, O. (2002). Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis. Gene, 283(1-2), 219-225.

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Genre: Journal Article
Alternative Title : Gene

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 Creators:
Braun, A.1, Author              
Aszodi, A.1, Author              
Hellebrand, H., Author
Berna, A., Author
Fässler, R.1, Author              
Brandau, O.2, Author              
Affiliations:
1Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              
2Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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Free keywords: profilin; cytoskeleton; SLC34A1; NPT2; spermatogenesis
 Abstract: Profilins are small, widely expressed actin binding proteins, thought to be key regulators of actin dynamics in living cells. So far, three profilin-genes have been described: profilin-I (PFNI), profilin-II (PEN2) with two splice variants and the recently identified profilin-III (PFN3). Here we describe the genomic organization of the genes encoding human and mouse profilin-Ill, Both are single exon genes and lie in close vicinity to the renal sodium-phosphate transport gene 2 (SLC34A1, NPT2) which is highly expressed in kidney. Northern hybridization to rat tissues has previously demonstrated expression of an approximately 4.5 kb long profilin-III mRNA transcript in kidney and a mRNA transcript of approximately 1 kb in length in testis. Here we show that mouse profilin-III expression is restricted to testis and that the 4.2 kb profilin-III mRNA in kidney is the result of a slc34a1 transcript which includes the antisense profilin-III open reading frame in its 3'-untranslated region. Finally, we demonstrate by in situ hybridization that profilin-III mRNA is localized to cells in the late stage of (C) 2002 Elsevier Science B.V. All rights reserved.

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Language(s): eng - English
 Dates: 2002-01-23
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 35289
ISI: 000174393400022
 Degree: -

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Title: Gene
  Alternative Title : Gene
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 283 (1-2) Sequence Number: - Start / End Page: 219 - 225 Identifier: ISSN: 0378-1119