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  Combined functional genomic maps of the C-elegans DNA damage response

Boulton, S. J., Gartner, A., Reboul, J., Vaglio, P., Dyson, N., Hill, D. E., et al. (2002). Combined functional genomic maps of the C-elegans DNA damage response. Science, 295(5552), 127-131.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-6FF6-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-6FF7-D
Genre: Journal Article
Alternative Title : Science

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 Creators:
Boulton, S. J., Author
Gartner, A.1, Author              
Reboul, J., Author
Vaglio, P., Author
Dyson, N., Author
Hill, D. E., Author
Vidal, M., Author
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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 Abstract: Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes remain to be discovered. To identify such genes, we used a strategy that combines protein- protein interaction mapping and large-scale phenotypic analysis in Caenorhabditis elegans. Together, these approaches identified 12 worm DDR orthologs and 11 novel DDR genes. One of these is the putative ortholog of hBCL3, a gene frequently altered in chronic lymphocytic leukemia. Thus, the combination of functional genomic mapping approaches in model organisms may facilitate the identification and characterization of genes involved in cancer and, perhaps, other human diseases.

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Language(s): eng - English
 Dates: 2002-01-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 35042
ISI: 000173143100049
 Degree: -

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Title: Science
  Alternative Title : Science
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 295 (5552) Sequence Number: - Start / End Page: 127 - 131 Identifier: ISSN: 0036-8075