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  Receptor tyrosine kinases as targets for anticancer drugs

Zwick, E., Bange, J., & Ullrich, A. (2002). Receptor tyrosine kinases as targets for anticancer drugs. Trends in Molecular Medicine, 8(1), 17-23.

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Genre: Journal Article
Alternative Title : Trends Mol. Med

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 Creators:
Zwick, E.1, Author
Bange, J.2, Author              
Ullrich, A.2, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Ullrich, Axel / Molecular Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565172              

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 Abstract: Receptor tyrosine kinases (RTKs) are the primary mediators of the signaling network that transmit extracellular signals into the cell. Gene amplification and/or overexpression of RTK proteins or functional alterations caused by mutations in the corresponding genes or abnormal autocrine-paracrine growth factor loops contribute to constitutive RTK signaling, ultimately resulting in the manifestation of dysregulated cell growth and cancer. The mechanism of uncontrolled RTK signaling that leads to cancer has provided the rationale for anti-RTK drug development. Strategies towards the prevention and interception of RTK signaling include monoclonal antibodies, small-molecule inhibitors, immunotoxins and antisense oligonucleotides.

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Language(s): eng - English
 Dates: 2002-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 35072
ISI: 000173187000004
 Degree: -

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Title: Trends in Molecular Medicine
  Alternative Title : Trends Mol. Med
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 8 (1) Sequence Number: - Start / End Page: 17 - 23 Identifier: ISSN: 1471-4914