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  Prospore membrane formation linked to the leading edge protein (LEP) coat assembly

Moreno-Borchart, A. C., Strasser, K., Finkbeiner, M. G., Shevchenko, A., Shevchenko, A., & Knop, M. (2001). Prospore membrane formation linked to the leading edge protein (LEP) coat assembly. EMBO Journal, 20(24), 6946-6957.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-70E4-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-70E5-8
Genre: Journal Article
Alternative Title : Embo J.

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 Creators:
Moreno-Borchart, A. C., Author
Strasser, K., Author
Finkbeiner, M. G., Author
Shevchenko, A., Author
Shevchenko, A., Author
Knop, M.1, Author              
Affiliations:
1Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565156              

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Free keywords: Ady3p; meiosis; membrane organization; spindle pole body; Ssp1p
 Abstract: In yeast, the differentiation process at the end of meiosis generates four daughter cells inside the boundaries of the mother cell. A meiosis-specific plaque (NIP) at the spindle pole bodies (SPBs) serves as the starting site for the formation of the prospore membranes (PSMs) that are destined to encapsulate the post-meiotic nuclei. Here we report the identification of Ady3p and Ssp1p, which are functional components of the leading edge protein (LEP) coat, that covers the ring-shaped opening of the PSMs. Ssp1p is required for the assembly of the LEP coat, which consists of at least three proteins (Ssp1p, Ady3p and Don1p). The assembly of the LEP coat starts with the formation of cytosolic precursors, which then bind in an Ady3p-dependent manner to the SPBs. Subsequent processes at the SPBs leading to functional LEP coats require Ssp1p and the NIP components. During growth of the PSMs, the LEP coat functions in formation of the cup-shaped membrane structure that is indispensable for the regulated cellularization of the cytoplasm around the post-meiotic nuclei.

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Language(s): eng - English
 Dates: 2001-12-17
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 35012
ISI: 000173050700002
 Degree: -

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Title: EMBO Journal
  Alternative Title : Embo J.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 20 (24) Sequence Number: - Start / End Page: 6946 - 6957 Identifier: ISSN: 0261-4189