ausblenden:
Schlagwörter:
Animal; *Cysteine Endopeptidases/ch [Chemistry]; Cysteine Endopeptidases/im [Immunology]; *Cysteine Endopeptidases/ph [Physiology]; Human; Models, Biological; Models, Immunological; Models, Molecular; *Multienzyme Complexes/ch [Chemistry]; Multienzyme Complexes/im [Immunology]; *Multienzyme Complexes/ph [Physiology]; Protein Conformation; Protein Folding
Zusammenfassung:
During the past two years, significant progress has been made in understanding the structure and function of the proteasome. Recent work has revealed the three-dimensional structure of the 700 kDa proteolytic complex at atomic resolution and elucidated its novel catalytic mechanism. Close relationships to a number of other amino-terminal hydrolases have emerged, making the proteasomal subunits the prototype of this newly discovered structural superfamily. [References: 75]
