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  Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample

Lill, C. M., Schjeide, B. M., Akkad, D. A., Blaschke, P., Winkelmann, A., Gerdes, L. A., et al. (2012). Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample. Neurogenetics, 13(1), 83-6. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22095036 http://www.springerlink.com/content/r9514vw301856238/fulltext.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7761-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7762-B
Genre: Journal Article

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Lill, C. M.1, Author              
Schjeide, B. M.1, Author              
Akkad, D. A., Author
Blaschke, P., Author
Winkelmann, A., Author
Gerdes, L. A., Author
Hoffjan, S., Author
Luessi, F., Author
Dorner, T., Author
Li, S. C., Author
Steinhagen-Thiessen, E., Author
Lindenberger, U., Author
Chan, A., Author
Hartung, H. P., Author
Aktas, O., Author
Lohse, P., Author
Kumpfel, T., Author
Kubisch, C., Author
Epplen, J. T., Author
Zettl, U. K., Author
Bertram, L.1, Author              Zipp, F., Author more..
Affiliations:
1Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479655              

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 Abstract: Recent genome-wide association studies have implicated the "signal transducer and activator of transcription 3" gene (STAT3) as a putative new multiple sclerosis (MS) susceptibility locus. However, independent validation studies are sparse. Therefore, we performed a genetic association study of two STAT3 polymorphisms (rs744166 and rs2293152) in a large and independent German case-control sample of 5,904 subjects. We observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio = 1.09, P = 0.012) in our sample. This study supports the association between STAT3 and an increase in MS risk. Taking into account the functional role of STAT3, our results favour an involvement of T(h)17 lymphocytes in MS.

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 Dates: 2012
 Publication Status: Published in print
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Title: Neurogenetics
Source Genre: Journal
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Pages: - Volume / Issue: 13 (1) Sequence Number: - Start / End Page: 83 - 6 Identifier: ISSN: 1364-6753 (Electronic) 1364-6745 (Linking)