English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The role of mitochondria in the aging processes of yeast

Breitenbach, M., Laun, P., Dickinson, J. R., Klocker, A., Rinnerthaler, M., Dawes, I. W., et al. (2012). The role of mitochondria in the aging processes of yeast. Sub-Cellular Biochemistry, 57, 55-78. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22094417 http://www.springerlink.com/content/v010167x7h8n7n82/fulltext.pdf.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7767-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7768-0
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Breitenbach, M., Author
Laun, P., Author
Dickinson, J. R., Author
Klocker, A., Author
Rinnerthaler, M., Author
Dawes, I. W., Author
Aung-Htut, M. T., Author
Breitenbach-Koller, L., Author
Caballero, A., Author
Nystrom, T., Author
Buttner, S., Author
Eisenberg, T., Author
Madeo, F., Author
Ralser, M.1, Author              
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

Content

show
hide
Free keywords: -
 Abstract: This chapter reviews the role of mitochondriamitochondria and of mitochondrial metabolismmetabolism in the aging processes of yeast and the existing evidence for the "mitochondrial theory of agingmitochondrial theory of aging ". MitochondriaMitochondria are the major source of ATPATP in the eukaryotic cell but are also a major source of reactive oxygen speciesreactive oxygen species (ROS) and play an important role in the process of apoptosisapoptosis and aging. We are discussing the mitochondrial theory of agingmitochondrial theory of aging (TOA), its origin, similarity with other TOAs, and its ramifications which developed in recent decades. The emphasis is on mother cell-specific agingmother cell-specific aging and the RLSRLS (replicative lifespan) with only a short treatment of CLSCLS (chronological lifespan). Both of these aging processes may be relevant to understand also the aging of higher organisms, but they are biochemically very different, as shown by the fact the replicative aging occurs on rich media and is a defect in the replicative capacity of mother cells, while chronological aging occurs in postmitotic cells that are under starvation conditions in stationary phase leading to loss of viability, as discussed elsewhere in this book. In so doing we also give an overview of the similarities and dissimilarities of the various aging processes of the most often used model organisms for aging research with respect to the mitochondrial theory of agingmitochondrial theory of aging .

Details

show
hide
Language(s):
 Dates: 2012
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Sub-Cellular Biochemistry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 57 Sequence Number: - Start / End Page: 55 - 78 Identifier: ISSN: 0306-0225 (Print) 0306-0225 (Linking)