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  A high-resolution anatomical atlas of the transcriptome in the mouse embryo

Diez-Roux, G., Banfi, S., Sultan, M., Geffers, L., Anand, S., Rozado, D., et al. (2011). A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol, 9(1), e1000582. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21267068 http://www.plosbiology.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pbio.1000582&representation=PDF.

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Diez-Roux, G., Autor
Banfi, S., Autor
Sultan, M.1, Autor           
Geffers, L., Autor
Anand, S., Autor
Rozado, D., Autor
Magen, A., Autor
Canidio, E., Autor
Pagani, M., Autor
Peluso, I., Autor
Lin-Marq, N., Autor
Koch, M., Autor
Bilio, M., Autor
Cantiello, I., Autor
Verde, R., Autor
De Masi, C., Autor
Bianchi, S. A., Autor
Cicchini, J., Autor
Perroud, E., Autor
Mehmeti, S., Autor
Dagand, E.2, Autor           Schrinner, S.1, Autor           Nurnberger, A.2, Autor           Schmidt, K., AutorMetz, K., AutorZwingmann, C., AutorBrieske, N.3, Autor           Springer, C., AutorHernandez, A. M., AutorHerzog, S., AutorGrabbe, F., AutorSieverding, C., AutorFischer, B., AutorSchrader, K., AutorBrockmeyer, M., AutorDettmer, S., AutorHelbig, C., AutorAlunni, V., AutorBattaini, M. A., AutorMura, C., AutorHenrichsen, C. N., AutorGarcia-Lopez, R., AutorEchevarria, D., AutorPuelles, E., AutorGarcia-Calero, E., AutorKruse, S., AutorUhr, M., AutorKauck, C., AutorFeng, G., AutorMilyaev, N., AutorOng, C. K., AutorKumar, L., AutorLam, M., AutorSemple, C. A., AutorGyenesei, A., AutorMundlos, S.3, Autor           Radelof, U.2, Autor           Lehrach, H.2, Autor           Sarmientos, P., AutorReymond, A., AutorDavidson, D. R., AutorDolle, P., AutorAntonarakis, S. E., AutorYaspo, M. L.1, Autor           Martinez, S., AutorBaldock, R. A., AutorEichele, G., AutorBallabio, A., Autor mehr..
Affiliations:
1Human Chromosome 21 (Marie-Laure Yaspo), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479652              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
3Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

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Schlagwörter: Animals; Atlases as Topic; *Databases, Genetic; Embryo, Mammalian; *Gene Expression Profiling; Internet; Mice/*anatomy & histology/embryology/*genetics; Mice, Inbred C57BL; Organ Specificity
 Zusammenfassung: Ascertaining when and where genes are expressed is of crucial importance to understanding or predicting the physiological role of genes and proteins and how they interact to form the complex networks that underlie organ development and function. It is, therefore, crucial to determine on a genome-wide level, the spatio-temporal gene expression profiles at cellular resolution. This information is provided by colorimetric RNA in situ hybridization that can elucidate expression of genes in their native context and does so at cellular resolution. We generated what is to our knowledge the first genome-wide transcriptome atlas by RNA in situ hybridization of an entire mammalian organism, the developing mouse at embryonic day 14.5. This digital transcriptome atlas, the Eurexpress atlas (http://www.eurexpress.org), consists of a searchable database of annotated images that can be interactively viewed. We generated anatomy-based expression profiles for over 18,000 coding genes and over 400 microRNAs. We identified 1,002 tissue-specific genes that are a source of novel tissue-specific markers for 37 different anatomical structures. The quality and the resolution of the data revealed novel molecular domains for several developing structures, such as the telencephalon, a novel organization for the hypothalamus, and insight on the Wnt network involved in renal epithelial differentiation during kidney development. The digital transcriptome atlas is a powerful resource to determine co-expression of genes, to identify cell populations and lineages, and to identify functional associations between genes relevant to development and disease.

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 Datum: 2011
 Publikationsstatus: Erschienen
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Titel: PLoS Biol
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 9 (1) Artikelnummer: - Start- / Endseite: e1000582 Identifikator: ISSN: 1545-7885 (Electronic) 1544-9173 (Linking)