English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Animal models with pathological mineralization phenotypes

Kornak, U. (2011). Animal models with pathological mineralization phenotypes. Joint Bone Spine, 78(6), 561-7. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21550285 http://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=272233&_user=28761&_pii=S1297319X11000789&_check=y&_origin=article&_zone=toolbar&_coverDate=31-Dec-2011&view=c&originContentFamily=serial&wchp=dGLzVBA-zSkzS&md5=418f55f8cdf675985ad1603de5bdfe9d/1-s2.0-S1297319X11000789-main.pdf.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-77FE-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-77FF-B
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Kornak, U.1, Author              
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

Content

show
hide
Free keywords: -
 Abstract: Extracellular matrix mineralization is important for mechanical stability of the skeleton and for calcium and phosphate storage. Professional mineral-disposing cell types are hypertrophic chondrocytes, odontoblasts, ameloblasts and osteoblasts. Since ectopic mineralization causes tissue dysfunction mineralization inhibitors and promoting factors have to be kept in close balance. The most prominent inhibitors are fetuin-A, matrix-Gla-protein (MGP), SIGBLING proteins and pyrophosphate. In spite of their ubiquitous presence, their loss entails a specific rather than a stereotypic pattern of ectopic mineralization. Typical sites of pathological mineral accumulation are connective tissues, articular cartilage, and vessels. Associated common human pathologies are degenerative joint disorders and arteriosclerosis. This article gives a summary on what we have learned from different mouse models with pathologic mineralization phenotypes about the role of these inhibitors and the regulation of mineralization promoting factors.

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Joint Bone Spine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 78 (6) Sequence Number: - Start / End Page: 561 - 7 Identifier: ISSN: 1778-7254 (Electronic) 1297-319X (Linking)