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  Ascending aortic aneurysm and aortic valve dysfunction in bicuspid aortic valve disease

Aydin, A., Desai, N., Bernhardt, A. M., Treede, H., Detter, C., Sheikhzadeh, S., et al. (2013). Ascending aortic aneurysm and aortic valve dysfunction in bicuspid aortic valve disease. International Journal of Cardiology, (164(3)), 301-305. doi:10.1016/j.ijcard.2011.07.018.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7800-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-1AAC-9
Genre: Journal Article

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Aydin, A., Author
Desai, N., Author
Bernhardt, A. M., Author
Treede, H., Author
Detter, C., Author
Sheikhzadeh, S., Author
Rybczynski, M., Author
Hillebrand, M., Author
Lorenzen, V., Author
Mortensen, K., Author
Robinson, P. N.1, Author              
Berger, J., Author
Reichenspurner, H., Author
Meinertz, T., Author
Willems, S., Author
von Kodolitsch, Y., Author
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

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 Abstract: BACKGROUND: The relationship of aortic valve dysfunction and ascending aortic aneurysm is unclear in adults with bicuspid aortic valve disease. METHODS: We retrospectively studied 134 consecutive out-patients (98 men, 36 women aged 43+/-18years) with bicuspid aortic valve disease. To investigate the relationship of ascending aortic aneurysm and aortic valve dysfunction we exclusively considered severe pathologies that required treatment by surgical or percutaneous intervention. RESULTS: Of 134 patients, 39 had aortic valve dysfunction without concomitant ascending aortic aneurysm which had been treated previously with isolated valve surgery or percutaneous valvuloplasty comprising 25 patients with aortic stenosis (19%) and 14 patients with aortic regurgitation (10%). Conversely, 26 patients had ascending aortic aneurysm which had been treated previously with aortic surgery (19%). Of these, ascending aortic aneurysm was associated with severe aortic stenosis in 13 patients and with severe aortic regurgitation in 7 patients, whereas aneurysm was unrelated to severe aortic valve dysfunction in the remaining 6 patients including 2 without any degree of aortic valve dysfunction. The maximal aortic diameters were similar at the time of aortic surgery irrespective of presence of severe aortic valve dysfunction (P=.527). Other characteristics of patients with ascending aortic aneurysm were also similar irrespective of presence or type of aortic valve dysfunction. CONCLUSION: The majority of patients with bicuspid aortic valve disease exhibit ascending aortic aneurysm in conjunction with severe aortic valve dysfunction. However, in our study 6 of 134 (5%) of persons with bicuspid aortic valve disease developed ascending aortic aneurysm without aortic valve dysfunction.

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Language(s): eng - English
 Dates: 2011-07-302013-04-15
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.ijcard.2011.07.018
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Title: International Journal of Cardiology
  Abbreviation : Int. J. Cardiol.
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: (164(3)) Sequence Number: - Start / End Page: 301 - 305 Identifier: ISSN: 0167-5273
CoNE: https://pure.mpg.de/cone/journals/resource/0167-5273