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  Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit

Muhs, M., Yamamoto, H., Ismer, J., Takaku, H., Nashimoto, M., Uchiumi, T., et al. (2011). Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit. Nucleic Acids Research, 39(12), 5264-75. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21378123 http://nar.oxfordjournals.org/content/39/12/5264.full.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-78EA-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-78EB-F
Genre: Journal Article

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 Creators:
Muhs, M., Author
Yamamoto, H.1, Author              
Ismer, J., Author
Takaku, H., Author
Nashimoto, M., Author
Uchiumi, T., Author
Nakashima, N., Author
Mielke, T.2, Author              
Hildebrand, P. W., Author
Nierhaus, K. H.3, Author              
Spahn, C. M.4, Author              
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
2Imaging/Electron Microscopy (Head: Rudi Lurz/Thorsten Mielke), Scientific Service (Head: Manuela B. Urban), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479668              
3Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433558              
4Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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Free keywords: *5' Untranslated Regions; Base Sequence; Dicistroviridae/*genetics; Models, Molecular; Molecular Sequence Data; Peptide Chain Initiation, Translational; RNA, Viral/*chemistry; Ribosomal Proteins/*chemistry/metabolism; Ribosome Subunits, Small, Eukaryotic/*chemistry; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins/*chemistry/metabolism
 Abstract: Some viruses exploit internal initiation for their propagation in the host cell. This type of initiation is facilitated by structured elements (internal ribosome entry site, IRES) upstream of the initiator AUG and requires only a reduced number of canonical initiation factors. An important example are IRES of the virus family Dicistroviridae that bind to the inter-subunit side of the small ribosomal 40S subunit and lead to the formation of elongation-competent 80S ribosomes without the help of any initiation factor. Here, we present a comprehensive functional and structural analysis of eukaryotic-specific ribosomal protein rpS25 in the context of this type of initiation and propose a structural model explaining the essential involvement of rpS25 for hijacking the ribosome.

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 Dates: 2011
 Publication Status: Published in print
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Title: Nucleic Acids Research
Source Genre: Journal
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Pages: - Volume / Issue: 39 (12) Sequence Number: - Start / End Page: 5264 - 75 Identifier: ISSN: 1362-4962 (Electronic) 0305-1048 (Linking)