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  The German multi-centre study on smoking-related behavior-description of a population-based case-control study

Lindenberg, A., Brinkmeyer, J., Dahmen, N., Gallinat, J., de Millas, W., Mobascher, A., et al. (2011). The German multi-centre study on smoking-related behavior-description of a population-based case-control study. Addict Biol, 16(4), 638-53. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21521423 http://onlinelibrary.wiley.com/store/10.1111/j.1369-1600.2011.00322.x/asset/j.1369-1600.2011.00322.x.pdf?v=1&t=gywopgjf&s=9daa30c5ea68deba1af73af47d2997ea201db8c9.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7999-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-799A-0
Genre: Journal Article

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 Creators:
Lindenberg, A., Author
Brinkmeyer, J., Author
Dahmen, N., Author
Gallinat, J., Author
de Millas, W., Author
Mobascher, A., Author
Wagner, M., Author
Schulze-Rauschenbach, S., Author
Grunder, G., Author
Spreckelmeyer, K. N., Author
Clepce, M., Author
Thurauf, N., Author
von der Goltz, C., Author
Kiefer, F., Author
Steffens, M., Author
Holler, D., Author
Diaz-Lacava, A., Author
Wienker, T.1, Author              
Winterer, G., Author
Affiliations:
1Clinical Genetics (Thomas F. Wienker), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479643              

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 Abstract: Tobacco smoking is a major risk factor for most of the diseases leading in mortality. Nicotine dependence (ND), which sustains regular smoking, is now acknowledged to be under substantial genetic control with some environmental contribution. At present, however, genetic studies on ND are mostly conducted in populations that have been poorly characterized with regard to ND-related phenotypes for the simple reason that the respective populations were not primarily collected to study ND. The German multi-centre study 'Genetics of Nicotine Dependence and Neurobiological Phenotypes', which is funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) as part of the Priority Program (Schwerpunktprogramm) SPP1226: 'Nicotine-Molecular and Physiological Effects in CNS', was intended to overcome some of these inherent problems of current genetic studies of ND. The multi-centre study is a population-based case-control study of smokers and never-smokers (n = 2396). The study was unique worldwide because it was the first large-scale genetic study specifically addressing ND with the collection of a wide range of environmental, psychosocial and neurobiological phenotypes. Study design and major population characteristics with emphasis on risk prediction of smoking status were presented in this paper.

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 Dates: 2011
 Publication Status: Published in print
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Title: Addict Biol
Source Genre: Journal
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Pages: - Volume / Issue: 16 (4) Sequence Number: - Start / End Page: 638 - 53 Identifier: ISSN: 1369-1600 (Electronic) 1355-6215 (Linking)