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Abstract:
Background: The Berlin Fat Mouse Inbred (BFMI) line is a new mouse model for obesity, which was long-term
selected for high fatness. Peroxisome proliferator-activated receptors (PPARs) are involved in the control of energy
homeostasis, nutrient metabolism and cell proliferation. Here, we studied the expression patterns of the different
Ppar genes and the genes in the PPAR pathway in the BFMI line in comparison to physiological changes.
Results: At the age of 10 weeks, the BFMI mice exhibited marked obesity with enlarged adipocytes and high
serum triglycerides concentrations in comparison to the often used mouse line C57BL/6 (B6). Between these two
lines, gene expression analyses revealed differentially expressed genes belonging to the PPAR pathway, in
particular genes of the lipogenesis and the fatty acid transport.
Conclusion: Surprisingly, the Ppar-a gene expression was up-regulated in liver and Ppar-g gene expression was
down-regulated in the white adipose tissue, indicating the activation of a mechanism that counteracts the rise of
obesity.
