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  Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity

Wagener, A., Goessling, H. F., Schmitt, A. O., Mauel, S., Gruber, A. D., Reinhardt, R., et al. (2010). Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity. Lipids in Health and Disease, 9, 9:99-9:99. doi:10.1186/1476-511X-9-999.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7A59-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7A5A-7
Genre: Journal Article
Alternative Title : Lipids Health Dis

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 Creators:
Wagener, Asja, Author
Goessling, Helge F., Author
Schmitt, Armin O., Author
Mauel, Susanne, Author
Gruber, Achim D., Author
Reinhardt, Richard1, Author              
Brockmann, Gudrun A., Author
Affiliations:
1High Throughput Technologies, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433552              

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 Abstract: Background: The Berlin Fat Mouse Inbred (BFMI) line is a new mouse model for obesity, which was long-term selected for high fatness. Peroxisome proliferator-activated receptors (PPARs) are involved in the control of energy homeostasis, nutrient metabolism and cell proliferation. Here, we studied the expression patterns of the different Ppar genes and the genes in the PPAR pathway in the BFMI line in comparison to physiological changes. Results: At the age of 10 weeks, the BFMI mice exhibited marked obesity with enlarged adipocytes and high serum triglycerides concentrations in comparison to the often used mouse line C57BL/6 (B6). Between these two lines, gene expression analyses revealed differentially expressed genes belonging to the PPAR pathway, in particular genes of the lipogenesis and the fatty acid transport. Conclusion: Surprisingly, the Ppar-a gene expression was up-regulated in liver and Ppar-g gene expression was down-regulated in the white adipose tissue, indicating the activation of a mechanism that counteracts the rise of obesity.

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Language(s): eng - English
 Dates: 2010-09-10
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
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Title: Lipids in Health and Disease
  Alternative Title : Lipids Health Dis
Source Genre: Journal
 Creator(s):
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Publ. Info: -
Pages: - Volume / Issue: 9 Sequence Number: - Start / End Page: 9:99 - 9:99 Identifier: ISSN: 1476-511X