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  The 2nd Berlin BedRest Study: protocol and implementation

Belavy, D. L., Bock, O., Borst, H., Armbrecht, G., Gast, U., Degner, C., et al. (2010). The 2nd Berlin BedRest Study: protocol and implementation. Journal of Musculoskeletal and Neuronal Interaction, 10(3), 207-219. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/20811145.

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Genre: Journal Article
Alternative Title : J Musculoskelet Neuronal Interact

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04BELAVY.pdf (Any fulltext), 556KB
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 Creators:
Belavy, D. L., Author
Bock, O., Author
Borst, H., Author
Armbrecht, G., Author
Gast, U., Author
Degner, C., Author
Beller, G., Author
Soll, H., Author
Salanova, M., Author
Habazettl, H., Author
Heer, M., Author
de Haan, A., Author
Stegeman, D. F., Author
Cerretelli, P., Author
Blottner, D., Author
Rittweger, J., Author
Gelfi, C., Author
Kornak, U.1, Author           
Felsenberg, D., Author
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

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Free keywords: Spaceflight; Microgravity; Countermeasures; Inactivity; Exercise
 Abstract: Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance exercise in preventing bone loss during bed-rest. Here we present the protocol of the study and discuss its implementation. Twenty-four male subjects underwent 60-days of six-degree head down tilt bed-rest and were randomised to an inactive control group (CTR), a high-load resistive exercise group (RE) or a high-load resistive exercise with whole-body vibration group (RVE). Subsequent to events in the course of the study (e.g. subject withdrawal), 9 subjects participated in the CTR-group, 7 in the RVE-group and 8 (7 beyond bed-rest day-30) in the RE-group. Fluid intake, urine output and axiallary temperature increased during bed-rest (p < .0001), though similarly in all groups (p > or = .17). Body weight changes differed between groups (p < .0001) with decreases in the CTR-group, marginal decreases in the RE-group and the RVE-group displaying significant decreases in body-weight beyond bed-rest day-51 only. In light of events and experiences of the current study, recommendations on various aspects of bed-rest methodology are also discussed.

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Language(s): eng - English
 Dates: 2010-09-01
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: eDoc: 539710
URI: http://www.ncbi.nlm.nih.gov/pubmed/20811145
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Title: Journal of Musculoskeletal and Neuronal Interaction
  Alternative Title : J Musculoskelet Neuronal Interact
Source Genre: Journal
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Pages: - Volume / Issue: 10 (3) Sequence Number: - Start / End Page: 207 - 219 Identifier: ISSN: 1108-7161