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  Cohort of Balanced Reciprocal Translocations Associated with Dyslexia: Identification of Two Putative Candidate Genes at DYX1.

Buonincontri, R., Bache, I., Silahtaroglu, A., Elbro, C., Veber Nielsen, A.-M., Ullmann, R., et al. (2010). Cohort of Balanced Reciprocal Translocations Associated with Dyslexia: Identification of Two Putative Candidate Genes at DYX1. Learning Disabilities, 125-133. doi:10.1007/s10519-010-9389-2.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7A76-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7A77-5
Genre: Journal Article
Alternative Title : Behav. Genet.

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 Creators:
Buonincontri, Roberta, Author
Bache, Iben, Author
Silahtaroglu, Asli, Author
Elbro, Carsten, Author
Veber Nielsen, Anne-Mette, Author
Ullmann, Reinhard1, Author              
Arkesteijn, Ger, Author
Tommerup, Niels, Author
Affiliations:
1Molecular Cytogenetics (Reinhard Ullmann), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479645              

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Free keywords: Dyslexia; Reciprocal translocations; DYX1; ZNF280D; TCF12; PDE7B; Brain comorbidity
 Abstract: Dyslexia is one of the most common neurodevelopmental disorders where likely many genes are involved in the pathogenesis. So far six candidate dyslexia genes have been proposed, and two of these were identified by rare chromosomal translocations in affected individuals. By systematic re-examination of all translocation carriers in Denmark, we have identified 16 different translocations associated with dyslexia. In four families, where the translocation co-segregated with the phenotype, one of the breakpoints concurred (at the cytogenetic level) with either a known dyslexia linkage region—at 15q21 (DYX1), 2p13 (DYX3) and 1p36 (DYX8)—or an unpublished linkage region at 19q13. As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21, and PDE7B at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.

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Language(s): eng - English
 Dates: 2010-08-27
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
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Title: Learning Disabilities
Source Genre: Issue
 Creator(s):
Grigorenko, Elena, Editor
Miller, Brett, Editor
Affiliations:
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Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 125 - 133 Identifier: -

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Title: Behavior Genetics: an International Journal Devoted to Research in the Inheritance of Behavior in Animals and man
  Alternative Title : Behav. Genet.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 41 (1) Sequence Number: - Start / End Page: - Identifier: ISSN: 1573-3297