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  Targetfinder.org: a resource for systematic discovery of transcription factor target genes

Kielbasa, S. M., Bluthgen, N., Fahling, M., & Mrowka, R. (2010). Targetfinder.org: a resource for systematic discovery of transcription factor target genes. Nucleic Acids Research, 38 Suppl, W233-W238. doi:10.1093/nar/gkq374.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7ABB-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7ABC-9
Genre: Journal Article
Alternative Title : Nucleic Acids Res

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 Creators:
Kielbasa, S. M.1, Author              
Bluthgen, N., Author
Fahling, M., Author
Mrowka, R.2, Author
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1Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              
2Max Planck Society, ou_persistent13              

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Free keywords: Gene Expression Profiling; Gene Expression Regulation; Internet; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Software; Transcription Factors/metabolism
 Abstract: Targetfinder.org (http://targetfinder.org/) provides a web-based resource for finding genes that show a similar expression pattern to a group of user-selected genes. It is based on a large-scale gene expression compendium (>1200 experiments, >13,000 genes). The primary application of Targetfinder.org is to expand a list of known transcription factor targets by new candidate target genes. The user submits a group of genes (the 'seed'), and as a result the web site provides a list of other genes ranked by similarity of their expression to the expression of the seed genes. Additionally, the web site provides information on a recovery/cross-validation test to check for consistency of the provided seed and the quality of the ranking. Furthermore, the web site allows to analyse affinities of a selected transcription factor to the promoter regions of the top-ranked genes in order to select the best new candidate target genes for further experimental analysis.

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Language(s): eng - English
 Dates: 2010-07-01
 Publication Status: Published in print
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Title: Nucleic Acids Research
  Alternative Title : Nucleic Acids Res
Source Genre: Journal
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Pages: - Volume / Issue: 38 Suppl Sequence Number: - Start / End Page: W233 - W238 Identifier: ISSN: 1362-4962 (Electronic) 0305-1048 (Linking) %R gkq374 [pii] 10.1093/nar/gkq374