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  Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice.

Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., et al. (2010). Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice. Science, 328(5979), 753-756. doi:10.1126/science.1186088.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7B23-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7B24-8
Genre: Journal Article
Alternative Title : Science

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 Creators:
Peleg, Shahaf, Author
Sananbenesi, Farahnaz, Author
Zovoilis, Athanasios, Author
Burkhardt, Susanne, Author
Bahari-Javan, Sanaz, Author
Agis-Balboa, Roberto Carlos, Author
Cota, Perla, Author
Wittnam, Jessica Lee, Author
Gogol-Doering, Andreas, Author
Opitz, Lennart, Author
Salinas-Riester, Gabriella, Author
Dettenhofer, Markus, Author
Kang, Hui1, Author              
Farinelli, Laurent, Author
Chen, Wei2, Author              
Fischer, André, Author
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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 Abstract: As the human life span increases, the number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying age-associated memory impairment are, however, not understood. Here we show that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation and fail to initiate a hippocampal gene expression program associated with memory consolidation. Restoration of physiological H4K12 acetylation reinstates the expression of learning-induced genes and leads to the recovery of cognitive abilities. Our data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the aging mouse brain.

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Language(s): eng - English
 Dates: 2010-05-07
 Publication Status: Published in print
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Title: Science
  Alternative Title : Science
Source Genre: Journal
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Pages: - Volume / Issue: 328 (5979) Sequence Number: - Start / End Page: 753 - 756 Identifier: ISSN: 0036-8075