English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.

von Kampen, O., Lipinski, S., Till, A., Martin, S. J., Nietfeld, W., Lehrach, H., et al. (2010). The caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling. He Journal of Biological Chemistry, 285(26), 19921-19926. doi:10.1074/jbc.M110.127480.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7B5A-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7B5B-E
Genre: Journal Article
Alternative Title : J Biol Chem

Files

show Files
hide Files
:
19921.full.pdf (Any fulltext), 2MB
 
File Permalink:
-
Name:
19921.full.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Molecular Genetics, MBMG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
eDoc_access: INSTITUT
License:
-

Locators

show

Creators

show
hide
 Creators:
von Kampen, O., Author
Lipinski, S., Author
Till, A., Author
Martin, S. J., Author
Nietfeld, W.1, Author              
Lehrach, H.1, Author              
Schreiber, S., Author
Rosenstiel, P., Author
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

Content

show
hide
Free keywords: Immunology Inflammation NF-κB Protein-Protein Interactions Signal Transduction CARD8 Caspase Recruitment Domain Crohn Disease NOD2
 Abstract: Caspase activating and recruitment domain 8 (CARD8) has been implicated as a co-regulator of several pro-inflammatory and apoptotic signaling pathways. In the present study, we demonstrate a specific modulation of NOD2-induced signaling by CARD8 in intestinal epithelial cells. We show that CARD8 physically interacts with NOD2 and inhibits nodosome assembly and subsequent signaling upon muramyl-dipeptide stimulation. Furthermore, CARD8 inhibits the direct bactericidal effect of NOD2 against intracellular infection by Listeria monocytogenes. Thus, CARD8 represents a novel molecular switch involved in the endogenous regulation of NOD2-dependent inflammatory processes in epithelial cells.

Details

show
hide
Language(s): eng - English
 Dates: 2010-04-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: He Journal of Biological Chemistry
  Alternative Title : J Biol Chem
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 285 (26) Sequence Number: - Start / End Page: 19921 - 19926 Identifier: ISSN: 0021-9258