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  The genome of a songbird.

Warren, W. C., Clayton, D. F., Ellegren, H., Arnold, A. P., Hillier, L. W., Kunstner, A., et al. (2010). The genome of a songbird. Nature, 464(7289), 757-762. doi:10.1038/nature08819.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7B6E-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7B6F-F
Genre: Journal Article
Alternative Title : Nat

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Warren, W. C., Author
Clayton, D. F., Author
Ellegren, H., Author
Arnold, A. P., Author
Hillier, L. W., Author
Kunstner, A., Author
Searle, S., Author
White, S., Author
Vilella, A. J., Author
Fairley, S., Author
Heger, A., Author
Kong, L., Author
Ponting, C. P., Author
Jarvis, E. D., Author
Mello, C. V., Author
Minx, P., Author
Lovell, P., Author
Velho, T. A., Author
Ferris, M., Author
Balakrishnan, C. N., Author
Sinha, S., AuthorBlatti, C., AuthorLondon, S. E., AuthorLi, Y., AuthorLin, Y. C., AuthorGeorge, J., AuthorSweedler, J., AuthorSouthey, B., AuthorGunaratne, P., AuthorWatson, M., AuthorNam, K., AuthorBackstrom, N., AuthorSmeds, L., AuthorNabholz, B., AuthorItoh, Y., AuthorWhitney, O., AuthorPfenning, A. R., AuthorHoward, J., AuthorVolker, M., AuthorSkinner, B. M., AuthorGriffin, D. K., AuthorYe, L., AuthorMcLaren, W. M., AuthorFlicek, P., AuthorQuesada, V., AuthorVelasco, G., AuthorLopez-Otin, C., AuthorPuente, X. S., AuthorOlender, T., AuthorLancet, D., AuthorSmit, A. F., AuthorHubley, R., AuthorKonkel, M. K., AuthorWalker, J. A., AuthorBatzer, M. A., AuthorGu, W., AuthorPollock, D. D., AuthorChen, L., AuthorCheng, Z., AuthorEichler, E. E., AuthorStapley, J., AuthorSlate, J., AuthorEkblom, R., AuthorBirkhead, T., AuthorBurke, T., AuthorBurt, D., AuthorScharff, C.1, Author              Adam, I., AuthorRichard, H.2, AuthorSultan, M.3, Author              Soldatov, A.4, Author              Lehrach, H.5, Author              Edwards, S. V., AuthorYang, S. P., AuthorLi, X., AuthorGraves, T., AuthorFulton, L., AuthorNelson, J., AuthorChinwalla, A., AuthorHou, S., AuthorMardis, E. R., AuthorWilson, R. K., Author more..
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
2Max Planck Society, ou_persistent13              
3Human Chromosome 21 (Marie-Laure Yaspo), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479652              
4Technology Development(Alexey Soldatov), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479657              
5Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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 Abstract: The zebra finch is an important model organism in several fields with unique relevance to human neuroscience. Like other songbirds, the zebra finch communicates through learned vocalizations, an ability otherwise documented only in humans and a few other animals and lacking in the chicken-the only bird with a sequenced genome until now. Here we present a structural, functional and comparative analysis of the genome sequence of the zebra finch (Taeniopygia guttata), which is a songbird belonging to the large avian order Passeriformes. We find that the overall structures of the genomes are similar in zebra finch and chicken, but they differ in many intrachromosomal rearrangements, lineage-specific gene family expansions, the number of long-terminal-repeat-based retrotransposons, and mechanisms of sex chromosome dosage compensation. We show that song behaviour engages gene regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs, transcription factors and their targets. We also show evidence for rapid molecular evolution in the songbird lineage of genes that are regulated during song experience. These results indicate an active involvement of the genome in neural processes underlying vocal communication and identify potential genetic substrates for the evolution and regulation of this behaviour.

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Language(s): eng - English
 Dates: 2010-04-01
 Publication Status: Published in print
 Pages: -
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Title: Nature
  Alternative Title : Nat
Source Genre: Journal
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Pages: - Volume / Issue: 464 (7289) Sequence Number: - Start / End Page: 757 - 762 Identifier: ISSN: 0028-0836