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  The genome of a songbird.

Warren, W. C., Clayton, D. F., Ellegren, H., Arnold, A. P., Hillier, L. W., Kunstner, A., et al. (2010). The genome of a songbird. Nature, 464(7289), 757-762. doi:10.1038/nature08819.

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Genre: Zeitschriftenartikel
Alternativer Titel : Nat

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nature08819.pdf (beliebiger Volltext), 952KB
 
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Warren, W. C., Autor
Clayton, D. F., Autor
Ellegren, H., Autor
Arnold, A. P., Autor
Hillier, L. W., Autor
Kunstner, A., Autor
Searle, S., Autor
White, S., Autor
Vilella, A. J., Autor
Fairley, S., Autor
Heger, A., Autor
Kong, L., Autor
Ponting, C. P., Autor
Jarvis, E. D., Autor
Mello, C. V., Autor
Minx, P., Autor
Lovell, P., Autor
Velho, T. A., Autor
Ferris, M., Autor
Balakrishnan, C. N., Autor
Sinha, S., AutorBlatti, C., AutorLondon, S. E., AutorLi, Y., AutorLin, Y. C., AutorGeorge, J., AutorSweedler, J., AutorSouthey, B., AutorGunaratne, P., AutorWatson, M., AutorNam, K., AutorBackstrom, N., AutorSmeds, L., AutorNabholz, B., AutorItoh, Y., AutorWhitney, O., AutorPfenning, A. R., AutorHoward, J., AutorVolker, M., AutorSkinner, B. M., AutorGriffin, D. K., AutorYe, L., AutorMcLaren, W. M., AutorFlicek, P., AutorQuesada, V., AutorVelasco, G., AutorLopez-Otin, C., AutorPuente, X. S., AutorOlender, T., AutorLancet, D., AutorSmit, A. F., AutorHubley, R., AutorKonkel, M. K., AutorWalker, J. A., AutorBatzer, M. A., AutorGu, W., AutorPollock, D. D., AutorChen, L., AutorCheng, Z., AutorEichler, E. E., AutorStapley, J., AutorSlate, J., AutorEkblom, R., AutorBirkhead, T., AutorBurke, T., AutorBurt, D., AutorScharff, C.1, Autor           Adam, I., AutorRichard, H.2, AutorSultan, M.3, Autor           Soldatov, A.4, Autor           Lehrach, H.5, Autor           Edwards, S. V., AutorYang, S. P., AutorLi, X., AutorGraves, T., AutorFulton, L., AutorNelson, J., AutorChinwalla, A., AutorHou, S., AutorMardis, E. R., AutorWilson, R. K., Autor mehr..
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
2Max Planck Society, ou_persistent13              
3Human Chromosome 21 (Marie-Laure Yaspo), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479652              
4Technology Development(Alexey Soldatov), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479657              
5Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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 Zusammenfassung: The zebra finch is an important model organism in several fields with unique relevance to human neuroscience. Like other songbirds, the zebra finch communicates through learned vocalizations, an ability otherwise documented only in humans and a few other animals and lacking in the chicken-the only bird with a sequenced genome until now. Here we present a structural, functional and comparative analysis of the genome sequence of the zebra finch (Taeniopygia guttata), which is a songbird belonging to the large avian order Passeriformes. We find that the overall structures of the genomes are similar in zebra finch and chicken, but they differ in many intrachromosomal rearrangements, lineage-specific gene family expansions, the number of long-terminal-repeat-based retrotransposons, and mechanisms of sex chromosome dosage compensation. We show that song behaviour engages gene regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs, transcription factors and their targets. We also show evidence for rapid molecular evolution in the songbird lineage of genes that are regulated during song experience. These results indicate an active involvement of the genome in neural processes underlying vocal communication and identify potential genetic substrates for the evolution and regulation of this behaviour.

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Sprache(n): eng - English
 Datum: 2010-04-01
 Publikationsstatus: Erschienen
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Titel: Nature
  Alternativer Titel : Nat
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 464 (7289) Artikelnummer: - Start- / Endseite: 757 - 762 Identifikator: ISSN: 0028-0836