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  Next-generation sequencing technologies for DNA methylation analyses in cancer genomics

Boerno, S. T., Grimm, C., Lehrach, H., & Schweiger, M.-R. (2010). Next-generation sequencing technologies for DNA methylation analyses in cancer genomics. Epigenomics, 2(2), 199-207. doi:10.2217/epi.09.50.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7B7A-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7B7B-4
Genre: Journal Article

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 Creators:
Boerno, Stefan T.1, Author
Grimm, Christina2, Author              
Lehrach, Hans3, Author              
Schweiger, Michal-Ruth4, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2In vitro Ligand Screening (Zoltán Konthur), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479653              
3Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
4Cancer Genomics (Michal-Ruth Schweiger), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479649              

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 Abstract: For the first time, the development of next-generation sequencing technologies has brought about tools to investigate epigenetic alterations in an unbiased, yet genome-wide approach. The importance of this innovative technology is undeniable since it has already been established that changes in DNA methylation play an important role in cancer initiation and progression. The first methylation maps have already been created, and it is only a matter of time until the complete epigenetic maps of healthy and diseased human genomes are available. In this review, we summarize the use of next-generation sequencing for diverse epigenetic technologies, give an overview of the status quo and outline future perspectives for its application in oncology and basic research.

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Language(s): eng - English
 Dates: 2010-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 547484
DOI: 10.2217/epi.09.50
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Title: Epigenomics
Source Genre: Journal
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Pages: - Volume / Issue: 2 (2) Sequence Number: - Start / End Page: 199 - 207 Identifier: ISSN: 1750-1911