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  An atlas of combinatorial transcriptional regulation in mouse and man.

Ravasi, T., Suzuki, H., Cannistraci, C. V., Katayama, S., Bajic, V. B., Tan, K., et al. (2010). An atlas of combinatorial transcriptional regulation in mouse and man. Cell, 140(5), 744-752. doi:10.1016/j.cell.2010.01.044.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7BAB-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7BAC-5
Genre: Journal Article
Alternative Title : Cell

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 Creators:
Ravasi, T., Author
Suzuki, H., Author
Cannistraci, C. V., Author
Katayama, S., Author
Bajic, V. B., Author
Tan, K., Author
Akalin, A., Author
Schmeier, S., Author
Kanamori-Katayama, M., Author
Bertin, N., Author
Carninci, P., Author
Daub, C. O., Author
Forrest, A. R., Author
Gough, J., Author
Grimmond, S., Author
Han, J. H., Author
Hashimoto, T., Author
Hide, W., Author
Hofmann, O., Author
Kamburov, A.1, Author              
Kaur, M., AuthorKawaji, H., AuthorKubosaki, A., AuthorLassmann, T., Authorvan Nimwegen, E., AuthorMacPherson, C. R., AuthorOgawa, C., AuthorRadovanovic, A., AuthorSchwartz, A., AuthorTeasdale, R. D., AuthorTegner, J., AuthorLenhard, B., AuthorTeichmann, S. A., AuthorArakawa, T., AuthorNinomiya, N., AuthorMurakami, K., AuthorTagami, M., AuthorFukuda, S., AuthorImamura, K., AuthorKai, C., AuthorIshihara, R., AuthorKitazume, Y., AuthorKawai, J., AuthorHume, D. A., AuthorIdeker, T., AuthorHayashizaki, Y., Author more..
Affiliations:
1Bioinformatics (Ralf Herwig), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479648              

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Free keywords: Animals; Cell Differentiation; Evolution, Molecular; Gene Expression Regulation; Gene Regulatory Networks; Humans; Mice; Monocytes/cytology; Organ Specificity; Smad3 Protein/metabolism; Trans-Activators/metabolism; Transcription Factors/*metabolism
 Abstract: Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across tissues, and that roughly half of the measured interactions are conserved between mouse and human. The data highlight the importance of TF combinations for determining cell fate, and they lead to the identification of a SMAD3/FLI1 complex expressed during development of immunity. The availability of large TF combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution.

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Language(s): eng - English
 Dates: 2010-03-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Cell
  Alternative Title : Cell
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 140 (5) Sequence Number: - Start / End Page: 744 - 752 Identifier: ISSN: 0092-8674