English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Histone modification levels are predictive for gene expression

Karlic, R., Chung, H. R., Lasserre, J., Vlahovicek, K., & Vingron, M. (2010). Histone modification levels are predictive for gene expression. Proceedings of the National Academy of Sciences USA, 107(7), 2926-2931. doi:10.073/pnas.0909344107.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7BDB-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7BDC-A
Genre: Journal Article
Alternative Title : Proc Natl Acad Sci USA

Files

show Files
hide Files
:
Karlic.pdf (Any fulltext), 304KB
Name:
Karlic.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
eDoc_access: PUBLIC
License:
-

Locators

show

Creators

show
hide
 Creators:
Karlic, R.1, Author              
Chung, H. R.2, Author              
Lasserre, J.1, Author              
Vlahovicek, K., Author
Vingron, M.3, Author              
Affiliations:
1Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              
2Computational Epigenetics (Ho-Ryun Chung), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479658              
3Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

Content

show
hide
Free keywords: CD4-Positive T-Lymphocytes/*metabolism; Computational Biology; CpG Islands/genetics; Gene Expression Regulation/*physiology; Histones/*metabolism; Humans; *Models, Biological; Promoter Regions, Genetic/genetics; Regression Analysis
 Abstract: Histones are frequently decorated with covalent modifications. These histone modifications are thought to be involved in various chromatin-dependent processes including transcription. To elucidate the relationship between histone modifications and transcription, we derived quantitative models to predict the expression level of genes from histone modification levels. We found that histone modification levels and gene expression are very well correlated. Moreover, we show that only a small number of histone modifications are necessary to accurately predict gene expression. We show that different sets of histone modifications are necessary to predict gene expression driven by high CpG content promoters (HCPs) or low CpG content promoters (LCPs). Quantitative models involving H3K4me3 and H3K79me1 are the most predictive of the expression levels in LCPs, whereas HCPs require H3K27ac and H4K20me1. Finally, we show that the connections between histone modifications and gene expression seem to be general, as we were able to predict gene expression levels of one cell type using a model trained on another one.

Details

show
hide
Language(s): eng - English
 Dates: 2010-02-16
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the National Academy of Sciences USA
  Alternative Title : Proc Natl Acad Sci USA
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 107 (7) Sequence Number: - Start / End Page: 2926 - 2931 Identifier: ISSN: 1091-6490 (Electronic)