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  Positioning of necrotic lobular intraepithelial neoplasias (LIN, grade3) within the sequence of breast carcinoma progression.

Boldt, V., Stacher, E., Halbwedl, I., Popper, H., Hultschig, C., Moinfar, F., et al. (2010). Positioning of necrotic lobular intraepithelial neoplasias (LIN, grade3) within the sequence of breast carcinoma progression. Genes Chromosomes Cancer, 49(5), 463-470. doi:10.1002/gcc.20756.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7BE1-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7BE2-B
Genre: Journal Article
Alternative Title : Genes Chromos Canc

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 Creators:
Boldt, Vivien1, Author              
Stacher, Elvira, Author
Halbwedl, Iris, Author
Popper, Helmut, Author
Hultschig, Claus2, Author
Moinfar, Farid, Author
Ullmann, Reinhard1, Author              
Tavassoli, Fattaneh A., Author
Affiliations:
1Molecular Cytogenetics (Reinhard Ullmann), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479645              
2Max Planck Society, ou_persistent13              

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 Abstract: Lobular intraepithelial neoplasia Grade 3 (LIN3) is a recently recognized variant of intraepithelial lobular neoplasia (LIN) of the breast composed of either uniform, generally small cells with massive lobular distension, pleomorphic cells, signet-ring cells, or any cell type with necrosis. In contrast to classic forms of LIN, there is no consensus on therapeutic strategies for LIN3. In part this is due to the paucity of molecular data that could assist in defining the relationship of LIN3 to classic LIN and carcinomas. In this study we have employed array comparative genomic hybridization to determine the patterns of chromosomal aberrations in nine LIN3 lesions. By comparison to array CGH data of 13 classic LIN lesions, we demonstrate that classic LIN and LIN3 share several recurrent changes, in particular gains of 1q and losses of 16q. Both aberrations are known to appear early in tumorigenesis and to be associated with good prognosis. However, apart from this overlap, there were a number of karyotypic features that were observed exclusively in LIN3. Clearly, this lesion was characterized by a significantly higher number of DNA copy number changes (9 vs. 31 on average), a considerable complexity of chromosomal rearrangements with more than 16 breakpoints in one chromosome and overlapping high copy amplifications encompassing a number of known oncogenes. Our data suggest that, at the genetic level, LIN3 represents a highly advanced lesion with considerable resemblance to carcinomas and, therefore, might represent the transition state from an intraepithelial neoplasm to breast carcinoma. © 2010 Wiley-Liss, Inc.

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Language(s): eng - English
 Dates: 2010-02-12
 Publication Status: Published in print
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Title: Genes Chromosomes Cancer
  Alternative Title : Genes Chromos Canc
Source Genre: Journal
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Pages: - Volume / Issue: 49 (5) Sequence Number: - Start / End Page: 463 - 470 Identifier: ISSN: 1098-2264