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  A small, variable, and irregular killer cell Ig-like receptor locus accompanies the absence of MHC-C and MHC-G in gibbons

Abi-Rached, L., Kuhl, H., Roos, C., ten Hallers, B., Zhu, B., Carbone, L., et al. (2010). A small, variable, and irregular killer cell Ig-like receptor locus accompanies the absence of MHC-C and MHC-G in gibbons. Journal of Immunology, 184(3), 1379-1391. doi:10.4049/jimmunol.0903016.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7BF1-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7BF2-7
Genre: Journal Article
Alternative Title : J Immunol

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 Creators:
Abi-Rached, Laurent, Author
Kuhl, Heiner1, Author              
Roos, Christian, Author
ten Hallers, Boudewijn, Author
Zhu, Baoli, Author
Carbone, Lucia, Author
de Jong, Pieter J., Author
Mootnick, Alan R., Author
Knaust, Florian2, Author
Reinhardt, Richard3, Author              
Parham, Peter, Author
Walter, Lutz, Author
Affiliations:
1Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Manuela B. Urban), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              
2Max Planck Society, ou_persistent13              
3High Throughput Technologies, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433552              

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 Abstract: The killer cell Ig-like receptors (KIRs) of NK cells recognize MHC class I ligands and function in placental reproduction and immune defense against pathogens. During the evolution of monkeys, great apes, and humans, an ancestral KIR3DL gene expanded to become a diverse and rapidly evolving gene family of four KIR lineages. Characterizing the KIR locus are three framework regions, defining two intervals of variable gene content. By analysis of four KIR haplotypes from two species of gibbon, we find that the smaller apes do not conform to these rules. Although diverse and irregular in structure, the gibbon haplotypes are unusually small, containing only two to five functional genes. Comparison with the predicted ancestral hominoid KIR haplotype indicates that modern gibbon KIR haplotypes were formed by a series of deletion events, which created new hybrid genes as well as eliminating ancestral genes. Of the three framework regions, only KIR3DL3 (lineage V), defining the 5' end of the KIR locus, is present and intact on all gibbon KIR haplotypes. KIR2DL4 (lineage I) defining the central framework region has been a major target for elimination or inactivation, correlating with the absence of its putative ligand, MHC-G, in gibbons. Similarly, the MHC-C–driven expansion of lineage III KIR genes in great apes has not occurred in gibbons because they lack MHC-C. Our results indicate that the selective forces shaping the size and organization of the gibbon KIR locus differed from those acting upon the KIR of other hominoid species.

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Language(s): eng - English
 Dates: 2010-02-01
 Publication Status: Published in print
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 Identifiers: eDoc: 460178
DOI: 10.4049/jimmunol.0903016
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Title: Journal of Immunology
  Alternative Title : J Immunol
Source Genre: Journal
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Pages: - Volume / Issue: 184 (3) Sequence Number: - Start / End Page: 1379 - 1391 Identifier: ISSN: 0022-1767