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  A global view of the nonprotein-coding transcriptome in Plasmodium falciparum

Raabe, C. A., Sanchez, C. P., Randau, G., Robeck, T., Skryabin, B. V., Chinni, S. V., et al. (2010). A global view of the nonprotein-coding transcriptome in Plasmodium falciparum. Nucleic Acids Research, 38(2), 608-617. doi:10.1093/nar/gkp895.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7C00-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7C01-E
Genre: Journal Article
Alternative Title : Nucleic Acids Res

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 Creators:
Raabe, Carsten A., Author
Sanchez, Cecilia P., Author
Randau, Gerrit, Author
Robeck, Thomas, Author
Skryabin, Boris V., Author
Chinni, Suresh V., Author
Kube, Michael1, Author              
Reinhardt, Richard1, Author              
Ng, Guey Hooi, Author
Manickam, Ravichandran, Author
Kuryshev, Vladimir Y., Author
Lanzer, Michael, Author
Brosius, Juergen, Author
Tang, Thean Hock, Author
Rozhdestvensky, Timofey S., Author
Affiliations:
1High Throughput Technologies, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433552              

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 Abstract: Nonprotein-coding RNAs (npcRNAs) represent an important class of regulatory molecules that act in many cellular pathways. Here, we describe the experimental identification and validation of the small npcRNA transcriptome of the human malaria parasite Plasmodium falciparum. We identified 630 novel npcRNA candidates. Based on sequence and structural motifs, 43 of them belong to the C/D and H/ACA-box subclasses of small nucleolar RNAs (snoRNAs) and small Cajal body-specific RNAs (scaRNAs). We further observed the exonization of a functional H/ACA snoRNA gene, which might contribute to the regulation of ribosomal protein L7a gene expression. Some of the small npcRNA candidates are from telomeric and subtelomeric repetitive regions, suggesting their potential involvement in maintaining telomeric integrity and subtelomeric gene silencing. We also detected 328 cis-encoded antisense npcRNAs (asRNAs) complementary to P. falciparum protein-coding genes of a wide range of biochemical pathways, including determinants of virulence and pathology. All cis-encoded asRNA genes tested exhibit lifecycle-specific expression profiles. For all but one of the respective sense–antisense pairs, we deduced concordant patterns of expression. Our findings have important implications for a better understanding of gene regulatory mechanisms in P. falciparum, revealing an extended and sophisticated npcRNA network that may control the expression of housekeeping genes and virulence factors.

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Language(s): eng - English
 Dates: 2010-02
 Publication Status: Published in print
 Pages: -
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Title: Nucleic Acids Research
  Alternative Title : Nucleic Acids Res
Source Genre: Journal
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Pages: - Volume / Issue: 38 (2) Sequence Number: - Start / End Page: 608 - 617 Identifier: ISSN: 0305-1048