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  CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid

Giedraitis, V., Glaser, A., Sarajarvi, T., Brundin, R., Gunnarsson, M. D., Schjeide, B. M., et al. (2010). CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid. Neuroscience Letters, 469(2), 265-267. doi:10.1016/j.neulett.2009.12.011.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7C0E-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7C0F-1
Genre: Journal Article
Alternative Title : Neurosci Lett

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 Creators:
Giedraitis, V., Author
Glaser, A., Author
Sarajarvi, T., Author
Brundin, R., Author
Gunnarsson, M. D., Author
Schjeide, B. M.1, Author              
Tanzi, R. E., Author
Helisalmi, S., Author
Pirttila, T., Author
Kilander, L., Author
Lannfelt, L., Author
Soininen, H., Author
Bertram, L.1, Author              
Ingelsson, M., Author
Hiltunen, M., Author
Affiliations:
1Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479655              

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Free keywords: Aged; Alzheimer Disease/cerebrospinal fluid/genetics/metabolism; Amyloid beta-Peptides/cerebrospinal fluid/metabolism; Biological Markers/cerebrospinal fluid/metabolism; Calcium Channels/genetics/metabolism; Cognition Disorders/cerebrospinal fluid/genetics/metabolism; Cohort Studies; European Continental Ancestry Group/genetics; Female; Finland; Genotype; Humans; Male; Membrane Glycoproteins/*genetics/metabolism; Peptide Fragments/*cerebrospinal fluid/metabolism; Phosphorylation; *Polymorphism, Genetic; Sequence Analysis, DNA; Sweden; tau Proteins/*cerebrospinal fluid/metabolism
 Abstract: Recently, the P86L alteration in CALHM1 (calcium homeostasis modulator-1) was reported to be associated with Alzheimer's disease (AD). Moreover, the risk allele increased amyloid-beta (A beta) levels in conditioned media from cultured cells. Therefore, we hypothesized that CALHM1 P86L may modulate A beta or tau levels in cerebrospinal fluid (CSF). Nearly 200 individuals with AD or other cognitive disorders were included for CSF analysis and CALHM1 genotyping. No significant differences in CSF levels of A beta 42, tau or phospho-tau were found across the various CALHM1 genotypes. In conclusion, we found no evidence that CALHM1 P86L is associated with altered CSF levels of the investigated AD biomarkers.

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Language(s): eng - English
 Dates: 2010-01-22
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 552741
DOI: 10.1016/j.neulett.2009.12.011
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Title: Neuroscience Letters
  Alternative Title : Neurosci Lett
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 469 (2) Sequence Number: - Start / End Page: 265 - 267 Identifier: ISSN: 1872-7972 (Electronic)