The CALHM1 P86L polymorphism is a genetic modifier of age at onset in 
Alzheimer's disease: a meta-analysis study

Lambert, J. C.; Sleegers, K.; Gonzalez-Perez, A.; Ingelsson, M.; Beecham, G. W.; Hiltunen, M.; Combarros, O.; Bullido, M. J.; Brouwers, N.; Bettens, K.; Berr, C.; Pasquier, F.; Richard, F.; Dekosky, S. T.; Hannequin, D.; Haines, J. L.; Tognoni, G.; Fievet, N.; Dartigues, J. F.; Tzourio, C.; Engelborghs, S.; Arosio, B.; Coto, E.; De Deyn, P.; Del Zompo, M.; Mateo, I.; Boada, M.; Antunez, C.; Lopez-Arrieta, J.; Epelbaum, J.; Schjeide, B. M.; Frank-Garcia, A.; Giedraitis, V.; Helisalmi, S.; Porcellini, E.; Pilotto, A.; Forti, P.; Ferri, R.; Delepine, M.; Zelenika, D.; Lathrop, M.; Scarpini, E.; Siciliano, G.; Solfrizzi, V.; Sorbi, S.; Spalletta, G.; Ravaglia, G.; Valdivieso, F.; Vepsalainen, S.; Alvarez, V.; Bosco, P.; Mancuso, M.; Panza, F.; Nacmias, B.; Bossu, P.; Hanon, O.; Piccardi, P.; Annoni, G.; Mann, D.; Marambaud, P.; Seripa, D.; Galimberti, D.; Tanzi, R. E.; Bertram, L.; Lendon, C.; Lannfelt, L.; Licastro, F.; Campion, D.; Pericak-Vance, M. A.; Soininen, H.; Van Broeckhoven, C.; Alperovitch, A.; Ruiz, A.; Kamboh, M. I.; Amouyel, P.

doi:10.3233/JAD-2010-100933

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The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study

Lambert, J. C., Sleegers, K., Gonzalez-Perez, A., Ingelsson, M., Beecham, G. W., Hiltunen, M., et al. (2010). The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. J Alzheimers Dis, 22(1), 247-255. doi:10.3233/JAD-2010-100933.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-7C98-9 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-7C99-7

Genre: Journal Article

Alternative Title : Journal of Alzheimers Disease

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Lambert, J. C., Author
Sleegers, K., Author
Gonzalez-Perez, A., Author
Ingelsson, M., Author
Beecham, G. W., Author
Hiltunen, M., Author
Combarros, O., Author
Bullido, M. J., Author
Brouwers, N., Author
Bettens, K., Author
Berr, C., Author
Pasquier, F., Author
Richard, F., Author
Dekosky, S. T., Author
Hannequin, D., Author
Haines, J. L., Author
Tognoni, G., Author
Fievet, N., Author
Dartigues, J. F., Author
Tzourio, C., Author
Engelborghs, S., AuthorArosio, B., AuthorCoto, E., AuthorDe Deyn, P., AuthorDel Zompo, M., AuthorMateo, I., AuthorBoada, M., AuthorAntunez, C., AuthorLopez-Arrieta, J., AuthorEpelbaum, J., AuthorSchjeide, B. M.¹, Author Frank-Garcia, A., AuthorGiedraitis, V., AuthorHelisalmi, S., AuthorPorcellini, E., AuthorPilotto, A., AuthorForti, P., AuthorFerri, R., AuthorDelepine, M., AuthorZelenika, D., AuthorLathrop, M., AuthorScarpini, E., AuthorSiciliano, G., AuthorSolfrizzi, V., AuthorSorbi, S., AuthorSpalletta, G., AuthorRavaglia, G., AuthorValdivieso, F., AuthorVepsalainen, S., AuthorAlvarez, V., AuthorBosco, P., AuthorMancuso, M., AuthorPanza, F., AuthorNacmias, B., AuthorBossu, P., AuthorHanon, O., AuthorPiccardi, P., AuthorAnnoni, G., AuthorMann, D., AuthorMarambaud, P., AuthorSeripa, D., AuthorGalimberti, D., AuthorTanzi, R. E., AuthorBertram, L.¹, Author Lendon, C., AuthorLannfelt, L., AuthorLicastro, F., AuthorCampion, D., AuthorPericak-Vance, M. A., AuthorSoininen, H., AuthorVan Broeckhoven, C., AuthorAlperovitch, A., AuthorRuiz, A., AuthorKamboh, M. I., AuthorAmouyel, P., Author more..

Affiliations:
1Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479655

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Free keywords: Age at onset; Alzheimer's disease; apolipoprotein E; CALHM1; polymorphism

Abstract: The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the epsilon4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the epsilon4 allele of the APOE gene.

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Language(s): eng - English

Dates: Date issued: 2010

Publication Status: Issued

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Identifiers: eDoc: 556531
DOI: 10.3233/JAD-2010-100933

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Title: J Alzheimers Dis

Alternative Title : Journal of Alzheimers Disease

Source Genre: Journal

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Pages: - Volume / Issue: 22 (1) Sequence Number: - Start / End Page: 247 - 255 Identifier: ISSN: 1875-8908 (Electronic)