The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 
and inhibits canonical Wnt signalling

van Wijk, Nicole Verhey; Witte, Florian; Feike, Ann Carolin; Schambony, Alexandra; Birchmeier, Walter; Mundlos, Stefan; Stricker, Sigmar

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The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling

van Wijk, N. V., Witte, F., Feike, A. C., Schambony, A., Birchmeier, W., Mundlos, S., et al. (2009). The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling. Biochemical and Biophysical Research Communications, 390(2), 211-216. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WBK-4X9TTRS-3-7&_cdi=6713&_user=127795&_pii=S0006291X09018956&_orig=browse&_coverDate=12%2F11%2F2009&_sk=996099997&view=c&wchp=dGLzVzz-zSkWb&md5=c9f5ca81e4f3eb0d7f3d49493d36036c&ie=/sdarticle.pdf.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-7CA0-6 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-7CA1-4

Genre: Zeitschriftenartikel

Alternativer Titel : Biochem Biophys Res Commun

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Urheber:
van Wijk, Nicole Verhey¹, Autor
Witte, Florian², Autor
Feike, Ann Carolin, Autor
Schambony, Alexandra, Autor
Birchmeier, Walter, Autor
Mundlos, Stefan³, Autor
Stricker, Sigmar³, Autor

Affiliations:
1Max Planck Society, ou_persistent13
2Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547
3Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557

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Schlagwörter: Wtip; Ror2; Brachydactyly; Wnt

Zusammenfassung: Wtip is a LIM domain protein of the Ajuba/Zyxin family involved in kidney and neural crest development; Ror2 is a receptor tyrosine kinase involved in the development of skeleton, heart, lung, genitalia and kidneys. Here we describe Wtip as an intracellular interaction partner of Ror2. Full-length Ror2 recruits Wtip to the cell membrane, a mutant involved in human disease fails to do so. Both genes and proteins show overlapping expression in the mouse embryo. We show that Wtip is able to inhibit canonical Wnt signalling in mammalian cells and in Xenopus embryos linking Wtip to a crucial developmental pathway.