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  The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling

van Wijk, N. V., Witte, F., Feike, A. C., Schambony, A., Birchmeier, W., Mundlos, S., et al. (2009). The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling. Biochemical and Biophysical Research Communications, 390(2), 211-216. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WBK-4X9TTRS-3-7&_cdi=6713&_user=127795&_pii=S0006291X09018956&_orig=browse&_coverDate=12%2F11%2F2009&_sk=996099997&view=c&wchp=dGLzVzz-zSkWb&md5=c9f5ca81e4f3eb0d7f3d49493d36036c&ie=/sdarticle.pdf.

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Genre: Journal Article
Alternative Title : Biochem Biophys Res Commun

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 Creators:
van Wijk, Nicole Verhey1, Author
Witte, Florian2, Author           
Feike, Ann Carolin, Author
Schambony, Alexandra, Author
Birchmeier, Walter, Author
Mundlos, Stefan3, Author           
Stricker, Sigmar3, Author           
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              
3Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

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Free keywords: Wtip; Ror2; Brachydactyly; Wnt
 Abstract: Wtip is a LIM domain protein of the Ajuba/Zyxin family involved in kidney and neural crest development; Ror2 is a receptor tyrosine kinase involved in the development of skeleton, heart, lung, genitalia and kidneys. Here we describe Wtip as an intracellular interaction partner of Ror2. Full-length Ror2 recruits Wtip to the cell membrane, a mutant involved in human disease fails to do so. Both genes and proteins show overlapping expression in the mouse embryo. We show that Wtip is able to inhibit canonical Wnt signalling in mammalian cells and in Xenopus embryos linking Wtip to a crucial developmental pathway.

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Language(s): eng - English
 Dates: 2009-12-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Biochemical and Biophysical Research Communications
  Alternative Title : Biochem Biophys Res Commun
Source Genre: Journal
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Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 390 (2) Sequence Number: - Start / End Page: 211 - 216 Identifier: ISSN: 0006-291X