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  Cohesin SMC1β protects telomeres in meiocytes

Adelfalk, C., Janschek, J., Revenkova, E., Blei, C., Liebe, B., Göb, E., et al. (2009). Cohesin SMC1β protects telomeres in meiocytes. Journal of Cell Biology, 187(2), 185-199. doi:10.1083/jcb.200808016.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7D02-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7D03-2
Genre: Journal Article
Alternative Title : J Cell Biol

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 Creators:
Adelfalk, Caroline1, Author              
Janschek, Johannes, Author
Revenkova, Ekaterina, Author
Blei, Cornelia, Author
Liebe, Bodo2, Author
Göb, Eva, Author
Alsheimer, Manfred, Author
Benavente, Ricardo, Author
de Boer, Esther, Author
Novak, Ivana, Author
Höög, Christer, Author
Scherthan, Harry1, Author              
Jessberger, Rolf, Author
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
2Max Planck Society, ou_persistent13              

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 Abstract: Meiosis-specific mammalian cohesin SMC1β is required for complete sister chromatid cohesion and proper axes/loop structure of axial elements (AEs) and synaptonemal complexes (SCs). During prophase I, telomeres attach to the nuclear envelope (NE), but in Smc1β–/– meiocytes, one fifth of their telomeres fail to attach. This study reveals that SMC1β serves a specific role at telomeres, which is independent of its role in determining AE/SC length and loop extension. SMC1β is necessary to prevent telomere shortening, and SMC3, present in all known cohesin complexes, properly localizes to telomeres only if SMC1β is present. Very prominently, telomeres in Smc1β–/– spermatocytes and oocytes loose their structural integrity and suffer a range of abnormalities. These include disconnection from SCs and formation of large telomeric protein–DNA extensions, extended telomere bridges between SCs, ring-like chromosomes, intrachromosomal telomeric repeats, and a reduction of SUN1 foci in the NE. We suggest that a telomere structure protected from DNA rearrangements depends on SMC1β.

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Language(s): eng - English
 Dates: 2009-10
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
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Title: Journal of Cell Biology
  Alternative Title : J Cell Biol
Source Genre: Journal
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Pages: - Volume / Issue: 187 (2) Sequence Number: - Start / End Page: 185 - 199 Identifier: ISSN: 0021-9525