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  Ribosomal proteins : role in ribosomal functions

Wilson, D. N., Gupta, R., Mikolajka, A., & Nierhaus, K. H. (2009). Ribosomal proteins: role in ribosomal functions. Encyclopedia of Life Sciences, 2009, 10-10. doi:10.1002/9780470015902.a0000687.pub3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7D0B-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7D0C-0
Genre: Journal Article

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 Creators:
Wilson, Daniel N.1, Author              
Gupta, Romi2, Author              
Mikolajka, Aleksandra, Author
Nierhaus, Knud H.2, Author              
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433558              

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Free keywords: rRNA-binding proteins; translational regulation; antitermination; antibiotic resistance; mutant proteins; binding of translational factors
 Abstract: The assignment of specific ribosomal functions to individual ribosomal proteins is difficult due to the enormous cooperativity of the ribosome; however, important roles for distinct ribosomal proteins are becoming evident. Although ribosomal ribonucleic acid (rRNA) has the major claim to certain aspects of ribosome function, such as decoding and peptidyltransferase activity, there are also protein-dominated functional hot-spots on the ribosome such as the messenger RNA (mRNA) entry pore, the translation factor-binding site and the exit of the ribosomal tunnel. The latter is binding site for both chaperones and complexes associated with protein transport through membranes. Furthermore, the contribution of ribosomal proteins is essential for the assembly and optimal functioning of the ribosome.

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Language(s): eng - English
 Dates: 2009-09-15
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
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Title: Encyclopedia of Life Sciences
Source Genre: Journal
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Pages: - Volume / Issue: 2009 Sequence Number: - Start / End Page: 10 - 10 Identifier: -