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  Inhibitors of the elongation cycle of protein synthesis

Wilson, D. N., Starosta, A. L., Yamamoto, H., & Nierhaus, K. H. (2009). Inhibitors of the elongation cycle of protein synthesis. Encyclopedia of Life Sciences, 2009, 13-13. doi:10.1002/9780470015902.a0000550.pub2.

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 Creators:
Wilson, Daniel N.1, Author              
Starosta, Agata L., Author
Yamamoto, Hiroshi2, Author              
Nierhaus, Knud H.3, Author              
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
3Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433558              

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Free keywords: Antibiotics; Ribosomes; RNA; Antibiotic resistance
 Abstract: The protein synthetic machinery is a highly complex apparatus that offers many potential sites for functional interference and represents a major target in the cell for antibiotics. The knowledge of ribosomal structure and function has progressed enormously in recent years, which has, in turn, accelerated our understanding of the mechanism of drug action. Conversely, drugs have been used as tools to probe the translation cycle, thus providing a means to further dissect the multitude of steps involved in protein synthesis. In an era where bacteria are showing an ever-increasing resistance to many clinically relevant antibiotics, the importance of understanding their mechanism of inhibition is essential to the development of novel and more effective replacements.

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Language(s): eng - English
 Dates: 2009-09-15
 Publication Status: Published in print
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 Table of Contents: -
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Title: Encyclopedia of Life Sciences
Source Genre: Journal
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Pages: - Volume / Issue: 2009 Sequence Number: - Start / End Page: 13 - 13 Identifier: -